PMID- 22796652
OWN - NLM
STAT- MEDLINE
DCOM- 20121121
LR  - 20220410
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 524
IP  - 1
DP  - 2012 Aug 22
TI  - Effect of melatonin on D-amphetamine-induced neuroglial alterations in postnatal 
      rat hippocampus and prefrontal cortex.
PG  - 1-4
LID - 10.1016/j.neulet.2012.06.077 [doi]
AB  - Amphetamine is a psychostimulant drug that produces long-lasting neurotoxic 
      effects on the central nervous system. Recent studies suggested that glia might 
      contribute to amphetamine-induced neuropathy. Excessive activation of astrocytes 
      can be deleterious to the neuron. Amphetamine-induced lesions during development 
      have the potential to produce numerous permanent abnormalities in neural 
      circuitry and function, including memory deficit. In the present study, postnatal 
      rats were injected with either saline or d-amphetamine for 7 consecutive days, 
      starting on postnatal day 4 (P4). Our results found that d-amphetamine caused a 
      marked increase in glia fibrillary acidic protein (GFAP), an astroglia marker, 
      expression that implicated astrogliosis in both hippocampus and prefrontal 
      cortex. The effect of d-amphetamine on hippocampal and prefrontal cortex neurons 
      was also investigated, and we detected a downregulation of betaIII-tubulin, a marker 
      of premature neuron expression. Furthermore, we found that pretreatment with 
      melatonin, a major hormone secreted from the pineal gland, prevented glial cell 
      activation and betaIII-tubulin reduction, caused by d-amphetamine in both 
      hippocampus and prefrontal cortex. The present study suggests that melatonin can 
      attenuate the detrimental effect of d-amphetamine on glial and neuronal cells.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Permpoonputtana, Kannika
AU  - Permpoonputtana K
AD  - Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol 
      University, Salaya, Nakornpathom 73170, Thailand.
FAU - Mukda, Sujira
AU  - Mukda S
FAU - Govitrapong, Piyarat
AU  - Govitrapong P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120713
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Biomarkers)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Tubulin)
RN  - CK833KGX7E (Amphetamine)
RN  - JL5DK93RCL (Melatonin)
SB  - IM
MH  - Amphetamine/*toxicity
MH  - Animals
MH  - Animals, Newborn
MH  - Astrocytes/drug effects/metabolism
MH  - Biomarkers/metabolism
MH  - Central Nervous System Stimulants/*toxicity
MH  - Female
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Hippocampus/cytology/*drug effects/metabolism
MH  - Male
MH  - Melatonin/*pharmacology
MH  - Neuroglia/cytology/*drug effects
MH  - Neurons/cytology/drug effects/metabolism
MH  - Neuroprotective Agents/*pharmacology
MH  - Prefrontal Cortex/cytology/*drug effects/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Tubulin/metabolism
EDAT- 2012/07/17 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/17 06:00
PHST- 2012/05/02 00:00 [received]
PHST- 2012/06/15 00:00 [revised]
PHST- 2012/06/16 00:00 [accepted]
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0304-3940(12)00909-3 [pii]
AID - 10.1016/j.neulet.2012.06.077 [doi]
PST - ppublish
SO  - Neurosci Lett. 2012 Aug 22;524(1):1-4. doi: 10.1016/j.neulet.2012.06.077. Epub 
      2012 Jul 13.