PMID- 22797132
OWN - NLM
STAT- MEDLINE
DCOM- 20130606
LR  - 20211021
IS  - 1433-9285 (Electronic)
IS  - 0933-7954 (Linking)
VI  - 48
IP  - 2
DP  - 2013 Feb
TI  - Psychosocial outcome in patients at clinical high risk of psychosis: a 
      prospective follow-up.
PG  - 303-11
LID - 10.1007/s00127-012-0545-2 [doi]
AB  - PURPOSE: In patients at clinical high risk (CHR) of psychosis, transition to 
      psychosis has been the focus of recent studies. Their broader outcome has 
      received less attention. We studied psychosocial state and outcome in CHR 
      patients. METHODS: In the European Prediction of Psychosis Study, 244 young 
      help-seeking CHR patients were assessed with the Strauss and Carpenter Prognostic 
      Scale (SCPS) at baseline, and 149 (61.1%) of them were assessed for the second 
      time at the 18-month follow-up. The followed patients were classified into poor 
      and good outcome groups. RESULTS: Female gender, ever-married/cohabitating 
      relationship, and good working/studying situation were associated with good 
      baseline SCPS scores. During follow-up, patients' SCPS scores improved 
      significantly. Good follow-up SCPS scores were predicted by higher level of 
      education, good working/studying status at baseline, and white ethnicity. 
      One-third of the followed CHR patients had poor global outcome. Poor 
      working/studying situation and lower level of education were associated with poor 
      global outcome. Transition to psychosis was associated with baseline, but not 
      with follow-up SCPS scores or with global outcome. CONCLUSION: The majority of 
      CHR patients experience good short-term recovery, but one-third have poor 
      psychosocial outcome. Good working situation is the major indicator of good 
      outcome, while low level of education and non-white ethnicity seem to be 
      associated with poor outcome. Transition to psychosis has little effect on 
      psychosocial outcome in CHR patients. In treating CHR patients, clinicians should 
      focus their attention on a broader outcome, and not only on preventing transition 
      to psychosis.
FAU - Salokangas, Raimo K R
AU  - Salokangas RK
AD  - Department of Psychiatry, University of Turku, 20520 Turku, Finland. 
      Raimo.K.R.Salokangas@tyks.fi
FAU - Nieman, Dorien H
AU  - Nieman DH
FAU - Heinimaa, Markus
AU  - Heinimaa M
FAU - Svirskis, Tanja
AU  - Svirskis T
FAU - Luutonen, Sinikka
AU  - Luutonen S
FAU - From, Tiina
AU  - From T
FAU - von Reventlow, Heinrich Graf
AU  - von Reventlow HG
FAU - Juckel, Georg
AU  - Juckel G
FAU - Linszen, Don
AU  - Linszen D
FAU - Dingemans, Peter
AU  - Dingemans P
FAU - Birchwood, Max
AU  - Birchwood M
FAU - Patterson, Paul
AU  - Patterson P
FAU - Schultze-Lutter, Frauke
AU  - Schultze-Lutter F
FAU - Klosterkotter, Joachim
AU  - Klosterkotter J
FAU - Ruhrmann, Stephan
AU  - Ruhrmann S
CN  - EPOS group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120715
PL  - Germany
TA  - Soc Psychiatry Psychiatr Epidemiol
JT  - Social psychiatry and psychiatric epidemiology
JID - 8804358
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Multivariate Analysis
MH  - *Outcome Assessment, Health Care
MH  - Patients/psychology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*epidemiology/psychology/therapy
MH  - Quality of Life/*psychology
MH  - Risk Factors
MH  - Sex Distribution
MH  - *Social Support
MH  - Socioeconomic Factors
MH  - Young Adult
EDAT- 2012/07/17 06:00
MHDA- 2013/06/07 06:00
CRDT- 2012/07/17 06:00
PHST- 2012/03/30 00:00 [received]
PHST- 2012/06/18 00:00 [accepted]
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2013/06/07 06:00 [medline]
AID - 10.1007/s00127-012-0545-2 [doi]
PST - ppublish
SO  - Soc Psychiatry Psychiatr Epidemiol. 2013 Feb;48(2):303-11. doi: 
      10.1007/s00127-012-0545-2. Epub 2012 Jul 15.