PMID- 22797694
OWN - NLM
STAT- MEDLINE
DCOM- 20121025
LR  - 20230610
IS  - 1546-1726 (Electronic)
IS  - 1097-6256 (Print)
IS  - 1097-6256 (Linking)
VI  - 15
IP  - 8
DP  - 2012 Jul 15
TI  - Dissecting spatial knowledge from spatial choice by hippocampal NMDA receptor 
      deletion.
PG  - 1153-9
LID - 10.1038/nn.3166 [doi]
AB  - Hippocampal NMDA receptors (NMDARs) and NMDAR-dependent synaptic plasticity are 
      widely considered crucial substrates of long-term spatial memory, although their 
      precise role remains uncertain. Here we show that Grin1(DeltaDGCA1) mice, lacking 
      GluN1 and hence NMDARs in all dentate gyrus and dorsal CA1 principal cells, 
      acquired the spatial reference memory water maze task as well as controls, 
      despite impairments on the spatial reference memory radial maze task. When we ran 
      a spatial discrimination water maze task using two visually identical beacons, 
      Grin1(DeltaDGCA1) mice were impaired at using spatial information to inhibit 
      selecting the decoy beacon, despite knowing the platform's actual spatial 
      location. This failure could suffice to impair radial maze performance despite 
      spatial memory itself being normal. Thus, these hippocampal NMDARs are not 
      essential for encoding or storing long-term, associative spatial memories. 
      Instead, we demonstrate an important function of the hippocampus in using spatial 
      knowledge to select between alternative responses that arise from competing or 
      overlapping memories.
FAU - Bannerman, David M
AU  - Bannerman DM
AD  - Department of Experimental Psychology, University of Oxford, Oxford, UK.
FAU - Bus, Thorsten
AU  - Bus T
FAU - Taylor, Amy
AU  - Taylor A
FAU - Sanderson, David J
AU  - Sanderson DJ
FAU - Schwarz, Inna
AU  - Schwarz I
FAU - Jensen, Vidar
AU  - Jensen V
FAU - Hvalby, Oivind
AU  - Hvalby O
FAU - Rawlins, J Nicholas P
AU  - Rawlins JN
FAU - Seeburg, Peter H
AU  - Seeburg PH
FAU - Sprengel, Rolf
AU  - Sprengel R
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 084655/WT_/Wellcome Trust/United Kingdom
GR  - 087736/WT_/Wellcome Trust/United Kingdom
GR  - 074385/WT_/Wellcome Trust/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120715
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 0 (Carrier Proteins)
RN  - 0 (Gprin1 protein, mouse)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
CIN - Nat Neurosci. 2012 Aug;15(8):1056-7. PMID: 22837031
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - Carrier Proteins/genetics
MH  - Dentate Gyrus/metabolism/physiopathology
MH  - Hippocampus/metabolism/*physiology
MH  - Maze Learning/physiology
MH  - Memory/*physiology
MH  - Mice
MH  - Nerve Tissue Proteins/*deficiency/genetics
MH  - Receptors, N-Methyl-D-Aspartate
MH  - Space Perception/physiology
PMC - PMC3442238
MID - UKMS48971
OID - NLM: UKMS48971
EDAT- 2012/07/17 06:00
MHDA- 2012/10/26 06:00
PMCR- 2013/02/01
CRDT- 2012/07/17 06:00
PHST- 2012/02/21 00:00 [received]
PHST- 2012/06/25 00:00 [accepted]
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2012/10/26 06:00 [medline]
PHST- 2013/02/01 00:00 [pmc-release]
AID - nn.3166 [pii]
AID - 10.1038/nn.3166 [doi]
PST - epublish
SO  - Nat Neurosci. 2012 Jul 15;15(8):1153-9. doi: 10.1038/nn.3166.