PMID- 22797969
OWN - NLM
STAT- MEDLINE
DCOM- 20130614
LR  - 20211021
IS  - 1432-1459 (Electronic)
IS  - 0340-5354 (Linking)
VI  - 260
IP  - 1
DP  - 2013 Jan
TI  - Microvascular imaging of asymptomatic MCA steno-occlusive patients using 
      ultra-high-field 7T MRI.
PG  - 144-50
LID - 10.1007/s00415-012-6604-5 [doi]
AB  - It is common that physicians are faced with patients who have severe 
      steno-occlusion of intracranial arteries in the absence of clinical symptoms. 
      This study is to determine whether a 7T magnetic resonance angiogram (MRA) could 
      provide the improved depiction of microvessels of asymptomatic patients with 
      steno-occlusive middle cerebral artery (MCA) and possible clues for diagnosis of 
      their clinical symptoms. All the patients who were identified as severe MCA 
      steno-occlusions underwent a 7T MRA study. Three of these also underwent 
      conventional angiography (TFCA). The vascular densities around the 
      steno-occlusive MCA and posterior cerebral artery (PCA) branches as control 
      vessels were measured and the difference between the median values of 7T and 3T 
      MRA data was also analyzed. The results of 7T MRA revealed numerous microvessels 
      not visible by conventional MRA. These 7T MRA images were also comparable to 
      those obtained by an invasive conventional angiography (TFCA). The median values 
      of vascular densities observed by 7T MRA were significantly higher than those by 
      3T MRA (5.28 at 7T vs. 1.45 at 3T for steno-occlusive MCA, p = 0.012, while 3.39 
      at 7T vs. 3.32 at 3T for normal PCA, p = 0.093). Ultra-high-field 7T MRA is a 
      totally noninvasive angiographic technique that is capable of visualizing 
      microvascular circulation that is usually difficult with conventional MRA. This 
      visualization technique, therefore, could provide an important avenue on the 
      diagnosis of steno-occlusion as well as the search of the roles of the 
      microvessel, especially collaterals, in the preservation of normal blood 
      circulation in patients with asymptomatic MCA steno-occlusion.
FAU - Cho, Zang-Hee
AU  - Cho ZH
AD  - Neuroscience Research Institute, Gachon University, 1198 Kuwol-dong, Namdong-gu, 
      Incheon, 405-760, Republic of Korea. zcho@gachon.ac.kr
FAU - Lee, Yeong-Bae
AU  - Lee YB
FAU - Kang, Chang-Ki
AU  - Kang CK
FAU - Yang, Ji-Won
AU  - Yang JW
FAU - Jung, In-Hye
AU  - Jung IH
FAU - Park, Chan-A
AU  - Park CA
FAU - Park, Cheol-Wan
AU  - Park CW
FAU - Kim, Young-Bo
AU  - Kim YB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120714
PL  - Germany
TA  - J Neurol
JT  - Journal of neurology
JID - 0423161
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain Mapping
MH  - Cerebral Angiography
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Infarction, Middle Cerebral Artery/*pathology
MH  - Magnetic Resonance Angiography
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Microvessels/*pathology
MH  - Middle Aged
EDAT- 2012/07/17 06:00
MHDA- 2013/06/15 06:00
CRDT- 2012/07/17 06:00
PHST- 2012/02/24 00:00 [received]
PHST- 2012/06/29 00:00 [accepted]
PHST- 2012/06/28 00:00 [revised]
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2013/06/15 06:00 [medline]
AID - 10.1007/s00415-012-6604-5 [doi]
PST - ppublish
SO  - J Neurol. 2013 Jan;260(1):144-50. doi: 10.1007/s00415-012-6604-5. Epub 2012 Jul 
      14.