PMID- 22798949 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20121002 LR - 20240321 IS - 1662-5161 (Electronic) IS - 1662-5161 (Linking) VI - 6 DP - 2012 TI - Performance monitoring and the medial prefrontal cortex: a review of individual differences and context effects as a window on self-regulation. PG - 197 LID - 10.3389/fnhum.2012.00197 [doi] LID - 197 AB - The medial prefrontal cortex (MPFC) is central to self-regulation and has been implicated in generating a cluster of event-related potential components, collectively referred to as medial frontal negativities (MFNs). These MFNs are elicited while individuals monitor behavioral and environmental consequences, and include the error-related negativity, Nogo N2, and the feedback-related negativity. A growing cognitive and affective neuroscience literature indicates that the activation of the anterior cingulate cortex (ACC) and surrounding medial prefrontal regions during performance monitoring is not only influenced by task context, but that these patterns of activity also vary as a function of individual differences (e.g., personality, temperament, clinical and non-clinical symptomatology, socio-political orientation, and genetic polymorphisms), as well as interactions between individual differences and task context. In this review we survey the neuroscience literature on the relations between performance monitoring, personality, task context, and brain functioning with a focus on the MPFC. We relate these issues to the role of affect in the paradigms used to elicit performance-monitoring neural responses and highlight some of the theoretical and clinical implications of this research. We conclude with a discussion of the complexity of these issues and how some of the basic assumptions required for their interpretation may be clarified with future research. FAU - van Noordt, Stefon J R AU - van Noordt SJ AD - Cognitive and Affective Neuroscience Laboratory, Department of Psychology, Brock University ON, Canada. FAU - Segalowitz, Sidney J AU - Segalowitz SJ LA - eng PT - Journal Article DEP - 20120711 PL - Switzerland TA - Front Hum Neurosci JT - Frontiers in human neuroscience JID - 101477954 PMC - PMC3394443 OTO - NOTNLM OT - ERN OT - FRN OT - Nogo N2 OT - anterior cingulate OT - individual differences OT - medial prefrontal cortex OT - performance monitoring OT - self-regulation EDAT- 2012/07/17 06:00 MHDA- 2012/07/17 06:01 PMCR- 2012/01/01 CRDT- 2012/07/17 06:00 PHST- 2012/03/09 00:00 [received] PHST- 2012/06/17 00:00 [accepted] PHST- 2012/07/17 06:00 [entrez] PHST- 2012/07/17 06:00 [pubmed] PHST- 2012/07/17 06:01 [medline] PHST- 2012/01/01 00:00 [pmc-release] AID - 10.3389/fnhum.2012.00197 [doi] PST - epublish SO - Front Hum Neurosci. 2012 Jul 11;6:197. doi: 10.3389/fnhum.2012.00197. eCollection 2012.