PMID- 22799202
OWN - NLM
STAT- MEDLINE
DCOM- 20140702
LR  - 20190923
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 30
IP  - 4
DP  - 2012 Apr
TI  - [Simultaneous determination of alendronate, pamidronate, ibandronate and 
      risedronate using ion chromatography with integrated pulsed amperometric 
      detection].
PG  - 414-8
AB  - A method for the simultaneous determination of alendronate, pamidronate, 
      ibandronate and risedronate using ion chromatography with integrated pulsed 
      amperometric detection (IPAD) has been developed. The electrochemical behavior 
      showed the catalytic currents of these bisphosphonates are based on the oxidation 
      of amines in their structures. Because the bisphosphonates are polar compounds 
      and present as anions under alkaline condition, therefore, they can be separated 
      by anion exchange chromatography. A Dionex AS18 column (250 mm x 2 mm) and an 
      AG18 column (50 mm x 2 mm) and 24 mmol/L NaOH solution were used for the 
      separation. Multi-step potential waveform parameters were optimized to maximize 
      the signal-to-noise ratio (S/N), which exhibited adsorption/desorption catalytic 
      features at the gold electrode surface in alkaline solution. Utilizing the 
      optimized waveform, the method showed good linearity (r2 = 0.9972 - 0.9995), 
      satisfactory repeatability (relative standard deviations (RSDs) of the peak areas 
      in the range of 0.84% - 1.37%) and sufficient sensitivity (limits of detection of 
      0.061 - 0.18 microg/mL) for the identification of the four bisphosphonates. The 
      recoveries were 80.81% - 97.32% with the RSDs of 1.46% - 3.02%. It is 
      demonstrated that this method is a rapid and simple one for the determination of 
      the four bisphosphonates in human plasma.
FAU - Chen, Yu
AU  - Chen Y
AD  - Hangzhou Vocational and Technical College, Hangzhou 310018, China.
FAU - Liu, Yuxiu
AU  - Liu Y
FAU - Chen, Zhidong
AU  - Chen Z
FAU - Chen, Meilan
AU  - Chen M
FAU - Zhu, Yan
AU  - Zhu Y
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Diphosphonates)
RN  - KM2Z91756Z (Risedronic Acid)
RN  - M2F465ROXU (Etidronic Acid)
RN  - OYY3447OMC (Pamidronate)
RN  - UMD7G2653W (Ibandronic Acid)
RN  - X1J18R4W8P (Alendronate)
SB  - IM
MH  - Alendronate/*blood
MH  - *Chromatography, Ion Exchange
MH  - Diphosphonates/*blood
MH  - Electrochemical Techniques
MH  - Etidronic Acid/*analogs & derivatives/blood
MH  - Humans
MH  - Ibandronic Acid
MH  - Pamidronate
MH  - Risedronic Acid
EDAT- 2012/07/18 06:00
MHDA- 2014/07/06 06:00
CRDT- 2012/07/18 06:00
PHST- 2012/07/18 06:00 [entrez]
PHST- 2012/07/18 06:00 [pubmed]
PHST- 2014/07/06 06:00 [medline]
AID - 10.3724/sp.j.1123.2011.12070 [doi]
PST - ppublish
SO  - Se Pu. 2012 Apr;30(4):414-8. doi: 10.3724/sp.j.1123.2011.12070.