PMID- 22799341
OWN - NLM
STAT- MEDLINE
DCOM- 20130130
LR  - 20190606
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 13
IP  - 4
DP  - 2012
TI  - Survival from synchronous bilateral breast cancer: the experience of surgeons 
      participating in the breast audit of the Society of Breast Surgeons of Australia 
      and New Zealand.
PG  - 1413-8
AB  - BACKGROUND: Previous studies generally indicate that synchronous bilateral breast 
      cancers (SBBC) have an equivalent or moderately poorer survival compared with 
      unilateral cases. The prognostic characteristics of SBBC would be relevant when 
      planning adjuvant therapies and follow-up medical surveillance. The frequency of 
      SBBC among early breast cancers in clinical settings in Australia and New Zealand 
      were investigated, plus their prognostic significance, using the Breast Cancer 
      Audit Database of the Society of Breast Surgeons of Australia and New Zealand, 
      which covered an estimated 60% of early invasive lesions in those countries. 
      DESIGN: Rate ratios (95% confidence limits) of SBBC were investigated among 
      35,370 female breast cancer cases by age of woman, histology type, grade, tumour 
      diameter, nodal status, lymphatic/vascular invasion and oestrogen receptor 
      status. Univariate and multivariable disease-specific survival analyses were 
      undertaken. RESULTS: 2.3% of cases were found to be SBBC (i.e., diagnoses 
      occurring within 3 months). The figure increased from 1.4% in women less than 40 
      years to 4.1% in those aged 80 years or more. Disease-specific survivals did not 
      vary by SBBC status (p=0.206). After adjusting for age, histology type, diameter, 
      grade, nodal status, lymphatic/vascular invasion, and oestrogen receptor status, 
      the relative risk of breast cancer death for SBBC was 1.17 (95% CL: 0.91, 1.51). 
      After adjusting for favourable prognostic factors more common in SBBC cases 
      (i.e., histology type, grade, lymphatic/ vascular invasion, and oestrogen 
      receptor status), the relative risk of breast cancer death for SBBC was 1.42 (95% 
      CL: 1.10, 1.82). After adjusting for unfavourable prognostic factors more common 
      in SBBC cases (i.e., older age and large tumour diameter), the relative risk of 
      breast cancer death for SBBC was 0.98 (95% CL: 0.76, 1.26). CONCLUSIONS: Results 
      confirm previous findings of an equivalent or moderately poorer survival for SBBC 
      but indicate that SBBC status is likely to be an important prognostic indicator 
      for some cases.
FAU - Roder, David
AU  - Roder D
AD  - Cancer Australia, Sydney, New South Wales. roder@internode.on.net
FAU - de Silva, Primali
AU  - de Silva P
FAU - Zorbas, Helen
AU  - Zorbas H
FAU - Kollias, James
AU  - Kollias J
FAU - Malycha, Peter
AU  - Malycha P
FAU - Pyke, Chris
AU  - Pyke C
FAU - Campbell, Ian
AU  - Campbell I
FAU - Webster, Fleur
AU  - Webster F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Australia/epidemiology
MH  - Breast Neoplasms/*mortality/*pathology
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Staging
MH  - Neoplasms, Multiple Primary/epidemiology/*mortality/*pathology
MH  - New Zealand/epidemiology
MH  - Prevalence
MH  - Prognosis
MH  - Proportional Hazards Models
EDAT- 2012/07/18 06:00
MHDA- 2013/01/31 06:00
CRDT- 2012/07/18 06:00
PHST- 2012/07/18 06:00 [entrez]
PHST- 2012/07/18 06:00 [pubmed]
PHST- 2013/01/31 06:00 [medline]
AID - 10.7314/apjcp.2012.13.4.1413 [doi]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2012;13(4):1413-8. doi: 10.7314/apjcp.2012.13.4.1413.