PMID- 22800638
OWN - NLM
STAT- MEDLINE
DCOM- 20130318
LR  - 20221207
IS  - 0253-9624 (Print)
IS  - 0253-9624 (Linking)
VI  - 46
IP  - 4
DP  - 2012 Apr
TI  - [Relationship between PPARgamma2 Pro12Ala polymorphism and type 2 diabetes mellitus 
      in Chinese Han population: a Meta-analysis].
PG  - 359-63
AB  - OBJECTIVE: To evaluate the relationship between peroxisome proliferator-activated 
      receptor-gamma2 (PPARgamma2) Pro12Ala polymorphism and type 2 diabetes mellitus (T2DM) in 
      Chinese Han population. METHODS: PubMed, Chinese Biomedicine Database (CBM), 
      China National Knowledge Infrastructure (CNKI) and Wanfang database were searched 
      for all relevant articles investigating the association between PPARgamma2 Pro12Ala 
      polymorphism and T2DM that were available from January, 1990 to June, 2011. A 
      total of 29 relevant articles were selected. A Meta-analysis was performed to 
      estimate heterogeneity and the pooled odds ratio (OR) to evaluate the 
      relationship between PPARgamma2 Pro12Ala polymorphism and T2DM. The sensitivity 
      analysis was also assessed. RESULTS: A total of 21 qualified articles including 
      3870 patients with T2DM and 3333 healthy controls were analyzed in the study. The 
      frequencies of the allele Ala12 in T2DM and control groups were 4.13% (320/7740) 
      and 4.56% (304/6666), respectively. There were not heterogeneity (chi(2) = 25.96, P 
      = 0.17) among the 21 qualified articles. The pooled OR (95%CI) value of the 
      frequencies of the PPARgamma2 genotype (PA + AA)/PP calculated by fixed effects model 
      was 0.96 (0.81 - 1.14) (P = 0.64). There was not heterogeneity among the 
      remaining articles after excluding the article with the largest weight and the 
      article with larger frequencies of the allele Ala12 respectively (chi(2) values 
      were 24.23, 16.87 respectively, both P values > 0.05). The pooled OR (95%CI) 
      value of the frequencies of the PPARgamma2 genotype (PA + AA)/PP of the remaining 
      articles were 1.01 (0.84 - 1.21) and 1.07 (0.89 - 1.28) after excluding the 
      article with the largest weight and the article with larger frequencies of the 
      allele Ala12 (both P values > 0.05). CONCLUSION: PPARgamma2 Pro12Ala polymorphism was 
      not associated with type 2 diabetes mellitus in Chinese Han population.
FAU - Tong, Jin-ying
AU  - Tong JY
AD  - Department of Epidemiology, Medical College of Hunan Normal University, Changsha 
      410006, China.
FAU - Huang, Nian
AU  - Huang N
FAU - Wang, Lei
AU  - Wang L
FAU - Yi, Yin-sha
AU  - Yi YS
FAU - Pan, Xi-hui
AU  - Pan XH
FAU - Lu, Yuan
AU  - Lu Y
LA  - chi
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - China
TA  - Zhonghua Yu Fang Yi Xue Za Zhi
JT  - Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
JID - 7904962
RN  - 0 (PPAR gamma)
SB  - IM
MH  - Alleles
MH  - Asian People/genetics
MH  - China
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - PPAR gamma/*genetics
MH  - *Polymorphism, Single Nucleotide
EDAT- 2012/07/18 06:00
MHDA- 2013/03/19 06:00
CRDT- 2012/07/18 06:00
PHST- 2012/07/18 06:00 [entrez]
PHST- 2012/07/18 06:00 [pubmed]
PHST- 2013/03/19 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yu Fang Yi Xue Za Zhi. 2012 Apr;46(4):359-63.