PMID- 22800820
OWN - NLM
STAT- MEDLINE
DCOM- 20121207
LR  - 20120717
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 125
IP  - 9
DP  - 2012 May
TI  - Outcome of surgery for sinus of Valsalva aneurysm with discrete membranous 
      subaortic stenosis.
PG  - 1552-5
AB  - BACKGROUND: Sinus of Valsalva aneurysm (SVA) is a rare cardiac anomaly, and SVA 
      with discrete membranous subaortic stenosis is even rarer. The aim of the study 
      was to make sure the incidence of SVA with discrete membraneous subaortic 
      stenosis in SVA and their surgical results. We retrospectively analyzed 234 
      patients receiving surgical repair of SVA and reported the incidence of 
      ventricular septal defect, aortic regurgitation, and discrete membranous 
      subaortic stenosis. We also reported seven cases of SVA combined with discrete 
      membranous subaortic stenosis and their surgical results. METHODS: Between 
      January 1999 and December 2009, seven patients of SVA with discrete membranous 
      subaortic stenosis underwent surgical repair of SVA and resection of subaortic 
      discrete membrane. There were six male and one female patients. The mean age was 
      (33.71 +/- 13.25) years (range 16 - 52 years). Associated cardiovascular lesions 
      were aortic regurgitation (n = 7), ventricular septal defect (n = 5), coarctation 
      of aorta (n = 1), bicuspid aortic valve (n = 1), patent ductus arteriosus (n = 
      1), and aortic valve stenosis (n = 1). The aortic valve was replaced in four 
      patients and valvuloplasty was done in three. The other co-existing anomalies 
      were corrected at the same time. All the seven patients were followed up from 18 
      to 125 months (mean (63.14 +/- 39.54) months). Among 234 SVA patients who underwent 
      surgical repair, the number of cases with coexisting ventricular septal defect, 
      aortic regurgitation, and discrete membranous subaortic stenosis was 129, 108, 
      and 7, respectively. RESULTS: There was neither early death after operation nor 
      late death during the follow-up period. All the seven patients were in the New 
      York Heart Association (NYHA) functional classes I and II. There was no 
      recurrence of discrete subaortic membrane during the follow-up period. The 
      incidence of ventricular septal defect, aortic valve incompetence, and discrete 
      membranous subaortic stenosis among 234 SVA patients was 55.13%, 46.15%, and 
      2.99%, respectively. CONCLUSIONS: Surgical repair of SVA with discrete membranous 
      subaortic stenosis showed good mid-term results. Resection of discrete subaortic 
      membrane should be done actively while repairing SVAs. Long-term results need to 
      be followed up.
FAU - Guo, Hong-Wei
AU  - Guo HW
AD  - Department of Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences and 
      Peking Union Medical College, Beijing 100037, China.
FAU - Chang, Qian
AU  - Chang Q
FAU - Yu, Cun-Tao
AU  - Yu CT
FAU - Sun, Xiao-Gang
AU  - Sun XG
FAU - Qian, Xiang-Yang
AU  - Qian XY
FAU - Hu, Sheng-Shou
AU  - Hu SS
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Discrete Subaortic Stenosis/pathology/*surgery
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sinus of Valsalva/pathology/*surgery
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2012/07/18 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/07/18 06:00
PHST- 2012/07/18 06:00 [entrez]
PHST- 2012/07/18 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2012 May;125(9):1552-5.