PMID- 22800888
OWN - NLM
STAT- MEDLINE
DCOM- 20121128
LR  - 20131121
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 125
IP  - 10
DP  - 2012 May
TI  - Serum uric acid levels correlate with atrial fibrillation in patients with 
      chronic systolic heart failure.
PG  - 1708-12
AB  - BACKGROUND: Studies have shown that increased levels of serum uric acid (SUA) are 
      associated with atrial fibrillation (AF). However, less is known about the 
      prognostic value of SUA levels for AF in patients with chronic heart failure 
      (CHF). The aim of the study was to examine the prognostic value of SUA levels for 
      AF in patients with CHF. METHODS: Sixteen thousand six hundred and eighty-one 
      patients diagnosed with CHF from 12 hospitals were analyzed. Patients were 
      categorized into AF group and non-AF group, death group, and survival group 
      according to the results of the patients' medical records and follow-up. 
      Univariate and multivariate Cox proportional hazards analyses were performed to 
      examine the risk of AF. The sensitivity and specificity of SUA level in 
      predicting the prognosis were examined by multivariate Cox models and receiver 
      operating characteristic (ROC) curves. RESULTS: The results of univariate 
      predictors in overall patients showed that the higher SUA level was associated 
      with AF. SUA level (HR, 1.084; 95%CI, 1.017 - 1.144; P < 0.001), diuretics (HR, 
      1.549; 95%CI, 1.246 - 1.854; P < 0.001), and New York Heart Association (NYHA) 
      (HR, 1.237; 95%CI, 1.168 - 1.306; P < 0.001) function class were the independent 
      risk factors for AF. The sensitivity and specificity of the models were 29.6% and 
      83.8% respectively for predicting AF. When SUA level was added to these models, 
      it remained significant (Wald c(2), 1494.88; P < 0.001 for AF); 58.8% (95%CI, 
      57.7% - 60.0%) of the observed results were concordant with the separate model. 
      CONCLUSION: Higher SUA level is associated strongly with AF in patients with CHF. 
      SUA level can increase the sensitivity and specificity in predicting AF.
FAU - Zhao, Qing-Yan
AU  - Zhao QY
AD  - Cardiovascular Research Institute of Wuhan University, Renmin Hospital of Wuhan 
      University, Wuhan, Hubei 430060, China.
FAU - Yu, Sheng-Bo
AU  - Yu SB
FAU - Huang, He
AU  - Huang H
FAU - Cui, Hong-Ying
AU  - Cui HY
FAU - Qin, Mu
AU  - Qin M
FAU - Huang, Ting
AU  - Huang T
FAU - Huang, Cong-Xin
AU  - Huang CX
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 268B43MJ25 (Uric Acid)
SB  - IM
MH  - Aged
MH  - Atrial Fibrillation/*blood
MH  - Female
MH  - Heart Failure, Systolic/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Uric Acid/*blood
EDAT- 2012/07/18 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/18 06:00
PHST- 2012/07/18 06:00 [entrez]
PHST- 2012/07/18 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2012 May;125(10):1708-12.