PMID- 22801072
OWN - NLM
STAT- MEDLINE
DCOM- 20130115
LR  - 20161125
IS  - 1558-2035 (Electronic)
IS  - 1558-2027 (Linking)
VI  - 13
IP  - 9
DP  - 2012 Sep
TI  - Renal function has an effect on cardiovascular mortality in patients with dilated 
      cardiomyopathy.
PG  - 554-8
LID - 10.2459/JCM.0b013e328356a2fd [doi]
AB  - BACKGROUND: Chronic heart failure (CHF) is a major and growing public health 
      problem resulting from the cardiac damage caused by a variety of disease 
      processes. CHF has many comorbid conditions such as hypertension, coronary artery 
      disease, peripheral artery disease and chronic kidney disease (CKD). Some of the 
      chronic conditions may have an effect on cardiac mortality in CHF patients. We 
      have investigated the effect of renal dysfunction on cardiovascular mortality in 
      patients with ischemic dilated cardiomyopathy (DCM) and nonischemic DCM. METHODS: 
      Six hundred and thirty-seven patients with DCM were evaluated between January 
      2003 and January 2011. All individuals in the study population were admitted to 
      the cardiology clinic because of decompensated heart failure. In this prospective 
      observational study, a total of 637 patients [409 men, 228 women, 18-94 years 
      old, mean age 63 +/- 13 years; New York Heart Association (NYHA) functional class 
      II-IV] with diagnoses of ischemic (402) and nonischemic (235) DCM were enrolled 
      in the study. Baseline glomerular filtration rate was calculated using the 
      Cockcroft-Gault equation. RESULTS: By the end of the study, 228 patients had died 
      due to cardiovascular reasons. Both DCM types had similar cardiovascular 
      mortality [151 patients with ischemic DCM (37%) vs. 77 patients with nonischemic 
      DCM (32%); P = NS]. Renal dysfunction had an effect on cardiovascular mortality 
      in patients with ischemic and nonischemic DCM (respectively, glomerular 
      filtration rate 54 +/- 24, 56 +/- 24; P < 0.001). CONCLUSION: We have demonstrated 
      that renal function is a prognostic risk marker in patients with ischemic and 
      nonischemic DCM.
FAU - Ertas, Gokhan
AU  - Ertas G
AD  - Bezmialem Vakif University, Faculty of Medicine, Department of Cardiology, 
      Istanbul, Turkey. drgokhanertas@yahoo.com.tr
FAU - Kozdag, Guliz
AU  - Kozdag G
FAU - Emre, Ender
AU  - Emre E
FAU - Vural, Ahmet
AU  - Vural A
FAU - Akbulut, Tayyar
AU  - Akbulut T
FAU - Ural, Dilek
AU  - Ural D
FAU - Goktekin, Omer
AU  - Goktekin O
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Cardiovasc Med (Hagerstown)
JT  - Journal of cardiovascular medicine (Hagerstown, Md.)
JID - 101259752
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiomyopathy, Dilated/complications/*mortality/physiopathology
MH  - Disease Progression
MH  - Echocardiography, Doppler
MH  - Female
MH  - Follow-Up Studies
MH  - Glomerular Filtration Rate/*physiology
MH  - Heart Ventricles/diagnostic imaging
MH  - Humans
MH  - Kidney/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Renal Insufficiency/diagnosis/*etiology/physiopathology
MH  - Survival Rate/trends
MH  - Turkey/epidemiology
MH  - Young Adult
EDAT- 2012/07/18 06:00
MHDA- 2013/01/16 06:00
CRDT- 2012/07/18 06:00
PHST- 2012/07/18 06:00 [entrez]
PHST- 2012/07/18 06:00 [pubmed]
PHST- 2013/01/16 06:00 [medline]
AID - 10.2459/JCM.0b013e328356a2fd [doi]
PST - ppublish
SO  - J Cardiovasc Med (Hagerstown). 2012 Sep;13(9):554-8. doi: 
      10.2459/JCM.0b013e328356a2fd.