PMID- 22801293
OWN - NLM
STAT- MEDLINE
DCOM- 20150819
LR  - 20151002
IS  - 2617-2402 (Electronic)
IS  - 0333-7308 (Linking)
VI  - 49
IP  - 2
DP  - 2012
TI  - Evidence for an association between brain-derived neurotrophic factor Val66Met 
      gene polymorphism and general intellectual ability in early-onset schizophrenia.
PG  - 137-42
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) plays a crucial role in the 
      survival, development and maintenance of neuronal systems, and the Val66Met 
      polymorphism has been implicated in memory functions. METHOD: We examined the 
      association of BDNF with general intellectual ability in 161 individuals 
      including 53 early-onset patients with schizophrenia (EOS), 91 healthy biological 
      relatives, and 17 relatives with major depressive disorder (MDD), using the 
      Wechsler Intelligence Scales (WISC). RESULTS: Regardless of diagnosis, 
      individuals with the Met66 allele had a significantly higher performance score 
      than those homozygous for Val66 on vocabulary, block design and object assembly 
      subtests of the WISC. EOS probands showed poor performance on all IQ subtests 
      compared with relatives with and without MDD. LIMITATIONS: Relatively smaller 
      sample size of individual genotypes. CONCLUSIONS: BDNF genotype may play a role 
      in specific cognitive functions and dimensions of intelligence. The Met allele 
      appears to be associated with superior performance in IQ compared with relatives 
      Val/Val genotype.
FAU - Vyas, Nora S
AU  - Vyas NS
AD  - Child Psychiatry Branch, National Institutes of Health, Bethesda, Maryland, 
      U.S.A. King's College London, Institute of Psychiatry, SGDP Centre and Department 
      of Psychosis Studies, London, U.K.
FAU - Puri, Basant K
AU  - Puri BK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Israel
TA  - Isr J Psychiatry Relat Sci
JT  - The Israel journal of psychiatry and related sciences
JID - 8108287
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Depressive Disorder, Major/genetics
MH  - Family
MH  - Female
MH  - Humans
MH  - Intelligence/*genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Schizophrenia/*genetics
MH  - Wechsler Scales
EDAT- 2012/07/18 06:00
MHDA- 2015/08/20 06:00
CRDT- 2012/07/18 06:00
PHST- 2012/07/18 06:00 [entrez]
PHST- 2012/07/18 06:00 [pubmed]
PHST- 2015/08/20 06:00 [medline]
PST - ppublish
SO  - Isr J Psychiatry Relat Sci. 2012;49(2):137-42.