PMID- 22803413
OWN - NLM
STAT- MEDLINE
DCOM- 20150505
LR  - 20120718
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 26
IP  - 9
DP  - 2012 May
TI  - [Expression and significance of MCM2, Ki-67 and Rb protein in laryngeal squamous 
      cell carcinomas].
PG  - 425-8
AB  - OBJECTIVE: To investigate the expression of MCM2, Ki-67 and Rb and its biological 
      characteristic in human laryngeal squamous cell carcinomas(LSCC). METHOD: The 
      expression of MCM2 protein and Rb protein were detected in 60 cases of LSCC, 10 
      cases of precarcinoma, 10 cases of vocal cord polyps and 10 cases of normal 
      laryngeal tissues, and Ki-67 protein were detected in 60 cases of LSCC and 10 
      cases of normal laryngeal tissues by Elivision plus immunohistochemical staining, 
      and analyze their relations with clinicopathological characteristics. RESULT: The 
      positive expression rate of MCM2 in LSCC was significantly higher than that in 
      precarcinoma and normal laryngeal tissues (P < 0.05), and was positively 
      correlated with pathological grades, clinical stages and lymph node metastases (P 
      < 0.05) of LSCC. The positive expression rate of Rb protein in LSCC was 
      significantly lower than that in precarcinoma and normal laryngeal tissues (P < 
      0.05). The expression level of MCM2 in LSCC was negatively corelated with Rb (r = 
      -0.542, P < 0.05), the expression level of Ki-67 in LSCC (76.67%) was 
      significantly higher than that in normal laryngeal tissues (30.00%) (P < 0.01) 
      and the expression level of MCM2 in LSCC was positively corelated with Ki-67(r = 
      0.596, P < 0.01). The LI of MCM2 in the 3-year survival rate of LSCC was 
      significantly lower than that in Ki-67 (P < 0.05). CONCLUSION: Over expression of 
      MCM2 and loss of Rb protein were related to the carcinogenesis and development of 
      LSCC. The determination of MCM2 can be an index for estimating the level of 
      malignancy and prognosis of LSCC.
FAU - Cai, Kaigui
AU  - Cai K
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, People's Hospital of 
      Guangzhou Huadu District, Guangzhou 510800, China.
FAU - Luo, Ying
AU  - Luo Y
FAU - Li, Lixiang
AU  - Li L
FAU - Liu, Yuehui
AU  - Liu Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Ki-67 Antigen)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Retinoblastoma Protein)
RN  - EC 3.6.4.12 (MCM2 protein, human)
RN  - EC 3.6.4.12 (Minichromosome Maintenance Complex Component 2)
SB  - IM
MH  - Carcinoma, Squamous Cell/*metabolism/mortality/pathology
MH  - Cell Cycle Proteins
MH  - Humans
MH  - Ki-67 Antigen/*metabolism
MH  - Laryngeal Neoplasms/*metabolism/mortality/pathology
MH  - Larynx/metabolism
MH  - Lymphatic Metastasis
MH  - Minichromosome Maintenance Complex Component 2/*metabolism
MH  - Neoplasm Proteins/*metabolism
MH  - Polyps/metabolism
MH  - Precancerous Conditions/metabolism/mortality/pathology
MH  - Retinoblastoma Protein/*metabolism
MH  - Survival Rate
MH  - Vocal Cords/metabolism
EDAT- 2012/07/19 06:00
MHDA- 2015/05/06 06:00
CRDT- 2012/07/19 06:00
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2015/05/06 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 May;26(9):425-8.