PMID- 22803423
OWN - NLM
STAT- MEDLINE
DCOM- 20131219
LR  - 20161018
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 32
IP  - 4
DP  - 2012 Apr
TI  - [Clinical effects of dalitong granule combined proton pump inhibitors on 
      gastroesophageal reflux disease].
PG  - 464-7
AB  - OBJECTIVE: To observe the clinical effects of Dalitong Granule (DG) combined 
      proton pump inhibitors (PPI) on gastroesophageal reflux disease (GERD). METHODS: 
      Totally 186 patients with GERD were randomly assigned to three groups, i.e., the 
      control group A (61 cases, only PPI group, Rabeprazole Capsule 20 mg, once 
      daily), the control group B (61 cases, PPI with domperidone group, Rabeprazole 20 
      mg, once daily; Domperidone 10 mg each time, thrice daily), and the experimental 
      group (64 cases, PPI + DG group, Rabeprazole 20 mg, once daily; DG, 6 g each 
      time, thrice daily). The treatment lasted for 4 weeks for all. The symptom 
      scoring, the overall efficacy, local efficacy, and adverse drug reactions were 
      compared among the three groups before and after treatment. RESULTS: Totally 183 
      patients completed the experiment. After 4 weeks of treatment, the symptom scores 
      in the three groups were significantly lowered. It was the lowest in the 
      experimental group with statistical difference (P < 0.01). The markedly effective 
      rate and the effective rate of the experimental group were significantly higher 
      than those of the control A and B groups. The local markedly effective rate and 
      the effective rate of the reflux esophagitis (RE) in the experimental group were 
      significantly higher than those of the control A and B groups (P<0.05). No 
      serious adverse reactions occurred in the three groups during the treatment 
      period. CONCLUSION: DG combined PPI could improve the symptoms of GERD safely and 
      effectively.
FAU - Zhang, Qing
AU  - Zhang Q
AD  - Department of Internal Medicine, Clinic Medical College of Yangtze University, 
      Hubei 434000.
FAU - Tan, Xiao-Ping
AU  - Tan XP
FAU - Wang, Wei-Zheng
AU  - Wang WZ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Proton Pump Inhibitors)
RN  - 32828355LL (Rabeprazole)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Female
MH  - Gastroesophageal Reflux/*drug therapy
MH  - Humans
MH  - Integrative Medicine
MH  - Male
MH  - Middle Aged
MH  - *Phytotherapy
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Rabeprazole/therapeutic use
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2012/07/19 06:00
MHDA- 2013/12/20 06:00
CRDT- 2012/07/19 06:00
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2013/12/20 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Apr;32(4):464-7.