PMID- 22803772
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20220316
IS  - 1557-8518 (Electronic)
IS  - 1540-4196 (Linking)
VI  - 10
IP  - 5
DP  - 2012 Oct
TI  - Impact of traits of metabolic syndrome on beta-cell function and insulin resistance 
      in normal fasting, normal glucose tolerant subjects.
PG  - 344-50
AB  - OBJECTIVE: Metabolic syndrome, impaired fasting glucose (IFG), and impaired 
      glucose tolerance (IGT) predict risk for type 2 diabetes mellitus (T2DM). To 
      determine if increased risk preceded development of these abnormalities, beta-cell 
      function and insulin resistance were assessed in euglycemic subjects with and 
      without traits of metabolic syndrome. METHODS: A total of 562 apparently healthy 
      Latin-American subjects were screened for metabolic syndrome [National Education 
      Cholesterol Program Adult Treatment Panel III (NECP ATP III)]. Early pancreatic 
      insulin response DeltaInsulin(0-30)/DeltaGlucose(0-30), Matsuda index, disposition index 
      (DI), and homeostasis model assessment of insulin resistance (HOMA-IR) ratio were 
      obtained from oral glucose tolerance testing (0-180 min). RESULTS: 
      DeltaI(0-30)/DeltaG(0-30), Matsuda index, DI, and HOMA-IR deteriorated in direct 
      proportion with number of traits of metabolic syndrome, and with increases in 
      glucose levels within the euglycemic range. DI was the most sensitive index. In 
      subjects with 1, 2, 3, and 4-5 traits, DI was 21.4%, 40%, 57%, and 76% lower, 
      respectively, than in subjects with no traits. As a single trait, abdominal 
      obesity was associated with insulin resistance, whereas, low high-density 
      lipoprotein cholesterol (HDL-C), alone or combined with high triglycerides, was 
      not associated with insulin resistance or beta-cell dysfunction. Combined 
      impairments in beta-cell function and insulin sensitivity were responsible for the 
      increases in fasting and 2-h plasma glucose concentrations within the euglycemic 
      range. CONCLUSIONS: Impaired beta-cell function and increased insulin resistance are 
      present much before development of metabolic syndrome, IFG, or IGT. beta-Cell 
      function and insulin sensitivity worsen in direct proportion with number of 
      traits of metabolic syndrome and increases in glucose levels. Compared to 
      abdominal obesity, low HDL-C+/-high triglycerides may bear a lesser weight in 
      predicting risk of T2DM.
FAU - Cubeddu, Luigi X
AU  - Cubeddu LX
AD  - Division of Metabolic and Cardiovascular Research, Health Professions Division, 
      Nova Southeastern University, Fort Lauderdale, Florida 33328, USA. 
      lcubeddu@nova.edu
FAU - Hoffmann, Irene S
AU  - Hoffmann IS
LA  - eng
PT  - Journal Article
DEP - 20120717
PL  - United States
TA  - Metab Syndr Relat Disord
JT  - Metabolic syndrome and related disorders
JID - 101150318
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis/metabolism
MH  - Blood Pressure/physiology
MH  - Fasting/blood/*metabolism/physiology
MH  - Female
MH  - Glucose Intolerance/metabolism/physiopathology
MH  - Glucose Tolerance Test
MH  - Health Status Indicators
MH  - Humans
MH  - Insulin/blood
MH  - *Insulin Resistance/physiology
MH  - Insulin-Secreting Cells/*physiology
MH  - Male
MH  - Metabolic Syndrome/*complications/etiology/metabolism/*physiopathology
MH  - Middle Aged
MH  - Risk Factors
EDAT- 2012/07/19 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/07/19 06:00
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - 10.1089/met.2012.0040 [doi]
PST - ppublish
SO  - Metab Syndr Relat Disord. 2012 Oct;10(5):344-50. doi: 10.1089/met.2012.0040. Epub 
      2012 Jul 17.