PMID- 22804918
OWN - NLM
STAT- MEDLINE
DCOM- 20131028
LR  - 20220410
IS  - 1365-2265 (Electronic)
IS  - 0300-0664 (Linking)
VI  - 78
IP  - 6
DP  - 2013 Jun
TI  - Neck circumference as a simple tool for identifying the metabolic syndrome and 
      insulin resistance: results from the Brazilian Metabolic Syndrome Study.
PG  - 874-81
LID - 10.1111/j.1365-2265.2012.04487.x [doi]
AB  - OBJECTIVE: To investigate the relationship of the neck circumference (NC) with 
      the metabolic syndrome (MetS) and insulin resistance (IR) in a large Brazilian 
      population-based sample, within a wide range of adiposity and glucose tolerance, 
      and to establish cut-off values of the NC for MetS and IR. CONTEXT: The NC 
      correlates with cardiovascular risk factors, IR and components of MetS. 
      Upper-body subcutaneous (sc) fat, as estimated by the NC, is associated with 
      cardiovascular risk factors as much as abdominal fat, which is usually estimated 
      by the waist circumference (WC). There are few epidemiological population-based 
      studies on the clinical significance of the NC to MetS and IR. DESIGN: This is a 
      cross-sectional study. PATIENTS: About 1053 Brazilian adults (18-60 years). 
      MEASUREMENTS: Patients with BMI 18.5-40.0 kg/m(2), with normal glucose tolerance 
      or type 2 diabetes (T2DM), were submitted to anthropometric measurements 
      including waist circumference (WC), NC and BMI. Abdominal visceral fat (VF) was 
      assessed by ultrasound. Insulin sensitivity (IS) was assessed by 
      euglycaemic-hyperinsulinaemic clamp (10% of total sample) and HOMA-IR. Spearman 
      correlations were used to evaluate the association between NC and IR and MetS 
      risk factors. Receiver operating characteristic (ROC) curves were used for 
      gender-specific cut-off values for the prediction of IR and MetS. Binary logistic 
      regression analysis was used to assess the chance of developing IR or MetS 
      according to the enlargement of NC and WC. RESULTS: The sample consisted of 28.6% 
      men, with a mean age of 39.4 (12 years). T2DM diagnosis was present in 306 
      individuals, of whom 34% were men. NC correlated with WC and BMI in both men and 
      women (P < 0.001). In both genders, NC showed a positive correlation with 
      triglycerides, fasting glucose, fasting insulin and HOMA-IR, and NC had a 
      negative association with high-density lipoprotein (HDL). NC and IS showed a 
      moderate negative correlation. A significant correlation was demonstrated between 
      VF and NC. In the ROC curves, NC presented the largest AUC for IR in women (P < 
      0.001), while NC presented a large AUC for MetS in both genders. CONCLUSIONS: 
      Neck circumference measurements are an alternative and innovative approach for 
      determining body fat distribution. The NC is positively associated with MetS risk 
      factors, IR and VF, with established cut-off values for the prediction of MetS 
      and IR.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Stabe, Christiane
AU  - Stabe C
AD  - Laboratory of Research in Metabolism and Diabetes, Department of Medical Clinic, 
      State University of Campinas UNICAMP, Campinas, Sao Paulo, Brazil. 
      chrisstabe@hotmail.com
FAU - Vasques, Ana Carolina Junqueira
AU  - Vasques AC
FAU - Lima, Marcelo Miranda Oliveira
AU  - Lima MM
FAU - Tambascia, Marcos Antonio
AU  - Tambascia MA
FAU - Pareja, Jose Carlos
AU  - Pareja JC
FAU - Yamanaka, Ademar
AU  - Yamanaka A
FAU - Geloneze, Bruno
AU  - Geloneze B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130325
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
SB  - IM
MH  - Adiposity
MH  - Adult
MH  - Body Mass Index
MH  - Brazil
MH  - Cardiovascular Diseases/etiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/diagnosis
MH  - Female
MH  - Humans
MH  - *Insulin Resistance
MH  - Intra-Abdominal Fat/diagnostic imaging
MH  - Male
MH  - Metabolic Syndrome/*diagnosis
MH  - Middle Aged
MH  - Neck/*anatomy & histology
MH  - Risk Factors
MH  - Ultrasonography
MH  - Waist Circumference
EDAT- 2012/07/19 06:00
MHDA- 2013/10/29 06:00
CRDT- 2012/07/19 06:00
PHST- 2012/02/29 00:00 [received]
PHST- 2012/04/01 00:00 [revised]
PHST- 2012/06/13 00:00 [revised]
PHST- 2012/06/26 00:00 [accepted]
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2013/10/29 06:00 [medline]
AID - 10.1111/j.1365-2265.2012.04487.x [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 2013 Jun;78(6):874-81. doi: 
      10.1111/j.1365-2265.2012.04487.x. Epub 2013 Mar 25.