PMID- 22804980
OWN - NLM
STAT- MEDLINE
DCOM- 20150416
LR  - 20191210
IS  - 1308-0032 (Electronic)
IS  - 1302-8723 (Linking)
VI  - 12
IP  - 7
DP  - 2012 Nov
TI  - Diagnostic value of heart-type fatty acid binding protein determined by the rapid 
      qualitative chromatographic immunoassay method for the detection of minor 
      myocardial damage in patients presenting with non-ST elevation acute coronary 
      syndrome.
PG  - 584-90
LID - 10.5152/akd.2012.185 [doi]
AB  - OBJECTIVE: The aim of this prospective study was to evaluate the diagnostic value 
      of heart-type fatty acid binding protein (H-FABP) determined by qualitative 
      immunoassay method for the detection of minor myocardial damage (MMD) in patients 
      with non-ST elevation acute coronary syndrome (NSTE-ACS). METHODS: The study 
      consisted of 62 patients with NSTE-ACS. Cardiac troponin I (cTnI) and creatine 
      kinase MB isoenzyme (CK-MB) values were measured at arrival. Myoglobin and H-FABP 
      were obtained if cTnI level was found to be elevated. A control group included 20 
      subjects with normal cTnI and CK-MB values. H-FABP was determined by a rapid 
      qualitative immunochromatographic test. Patients were classified as MMD-ACS group 
      if they had abnormal cTnI and normal CK-MB (n=24) and as NSTEMI-ACS group if they 
      had elevated both cTnI and CK-MB (n=38). The diagnostic accuracy of H-FABP for 
      minor myocardial damage was determined using ROC analysis. RESULTS: The 
      sensitivity of the H-FABP was significantly higher for NSTEMI-ACS than for 
      MMD-ACS (44.7% vs 0%, p<0.001) and its specificity was 95% for both groups. The 
      diagnostic efficacy rates for myoglobin and H-FABP were 75% and 43% for MMD-ACS, 
      74% and 62% for NSTEMI-ACS. Positive predictive value for H-FABP and myoglobin 
      were found to be 0% and 80.8% in MMD-ACS, 94% and 87% in NSTEMI-ACS and negative 
      predictive value was 44% and 69.5% in MMD-ACS, 47.5% and 59% in NSTEMI-ACS, 
      respectively. AUC for myoglobin was significantly greater than that for H-FABP in 
      MMD-ACS group (0.754 vs 0.525, p=0.027). The sensitivity of the H-FABP was 
      significantly higher in patients with >3-fold increase in cTnI than those with 
      <3-fold increase in cTnI (46.8% vs. 6.7%, p<0.001). A positive correlation was 
      found between the magnitude of cTnI rise and H-FABP results (r=0.45, p<0.001). 
      CONCLUSIONS: H-FABP determined by the rapid qualitative immunochromatographic 
      test has almost similar diagnostic value to that of myoglobin for identifying 
      NSTEMI-ACS, however, does not seem to represent diagnostic potential for the 
      detection of MMD.
FAU - Cavusoglu, Yuksel
AU  - Cavusoglu Y
AD  - Department of Cardiology, Faculty of Medicine, Eskisehir Osmangazi University, 
      Eskisehir-Turkey. yukselc@ogu.edu.tr
FAU - Gok, Bulent
AU  - Gok B
FAU - Demirustu, Canan
AU  - Demirustu C
FAU - Birdane, Alparslan
AU  - Birdane A
FAU - Gorenek, Bulent
AU  - Gorenek B
FAU - Ata, Necmi
AU  - Ata N
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20120717
PL  - Turkey
TA  - Anadolu Kardiyol Derg
JT  - Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology
JID - 101095069
RN  - 0 (Biomarkers)
RN  - 0 (Fatty Acid-Binding Proteins)
SB  - IM
MH  - Acute Coronary Syndrome/blood/*diagnosis
MH  - Aged
MH  - Biomarkers/blood
MH  - Fatty Acid-Binding Proteins/*blood
MH  - Female
MH  - Heart Conduction System
MH  - Humans
MH  - Male
MH  - Myocardial Infarction/blood/*diagnosis
MH  - Prospective Studies
MH  - ROC Curve
MH  - Sensitivity and Specificity
EDAT- 2012/07/19 06:00
MHDA- 2015/04/17 06:00
CRDT- 2012/07/19 06:00
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2015/04/17 06:00 [medline]
AID - 10.5152/akd.2012.185 [doi]
PST - ppublish
SO  - Anadolu Kardiyol Derg. 2012 Nov;12(7):584-90. doi: 10.5152/akd.2012.185. Epub 
      2012 Jul 17.