PMID- 22805474
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20120718
IS  - 1365-2222 (Electronic)
IS  - 0954-7894 (Linking)
VI  - 42
IP  - 8
DP  - 2012 Aug
TI  - Skin prick test and specific serum IgE in the diagnostic evaluation of suspected 
      cow's milk and hen's egg allergy in children: does one replace the other?
PG  - 1266-72
LID - 10.1111/j.1365-2222.2012.04046.x [doi]
AB  - BACKGROUND: The measurement of specific serum immunoglobulin E (sIgE) and the 
      skin prick test (SPT) are accepted tools in the diagnostic work-up of suspected 
      food allergy. Often only one of the methods is used to determine sensitization; 
      however, it is still under debate whether these two methods can be used 
      interchangeably. OBJECTIVES: To investigate the concordance of SPT and sIgE serum 
      assays with regard to suspected food allergy. METHODS: In 395 children referred 
      to our clinic with suspected cow's milk allergy and in 268 children with 
      suspected hen's egg allergy specific immunoglobulin E (IgE) was measured, a SPT 
      and an oral food challenge performed. A weal size >/= 3 mm and sIgE >/= 0.35 kU/L 
      were considered positive. The weal size of the SPT and the level of food-specific 
      IgE were tested for correlation for each allergen. RESULTS: Of the 395 (23%) 
      children orally challenged with cow's milk, 92 showed no corresponding results 
      for SPT and sIgE as either positive or negative. For hen's egg, in 27 of 268 
      (10%) children differing test results for SPT and sIgE in serum were obtained. 
      Moreover, regarding the quantitative values for sIgE and SPT in children with or 
      without clinically relevant food allergy, sIgE and SPT correlated badly. 
      CONCLUSIONS: The concordance between SPT and sIgE is surprisingly low for cow's 
      milk and hen's egg on an individual basis. Therefore, the tests should not be 
      used interchangeably. Especially in children who receive a negative test result 
      the alternative test should also be used. Furthermore, our data indicate again 
      that oral food challenges are still the method of choice to diagnose food 
      allergies.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Mehl, A
AU  - Mehl A
AD  - Department of Pediatric Pneumology and Immunology, Charite University Medical 
      Center, Berlin, Germany.
FAU - Niggemann, B
AU  - Niggemann B
FAU - Keil, T
AU  - Keil T
FAU - Wahn, U
AU  - Wahn U
FAU - Beyer, K
AU  - Beyer K
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Exp Allergy
JT  - Clinical and experimental allergy : journal of the British Society for Allergy 
      and Clinical Immunology
JID - 8906443
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Administration, Oral
MH  - Adolescent
MH  - Allergens/administration & dosage/immunology
MH  - Animals
MH  - Antibody Specificity/immunology
MH  - Child
MH  - Child, Preschool
MH  - Egg Hypersensitivity/*diagnosis/immunology
MH  - Eggs/adverse effects
MH  - Humans
MH  - Immunoglobulin E/*blood/immunology
MH  - Infant
MH  - Milk/adverse effects
MH  - Milk Hypersensitivity/*diagnosis/immunology
MH  - *Skin Tests
EDAT- 2012/07/19 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/07/19 06:00
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 10.1111/j.1365-2222.2012.04046.x [doi]
PST - ppublish
SO  - Clin Exp Allergy. 2012 Aug;42(8):1266-72. doi: 10.1111/j.1365-2222.2012.04046.x.