PMID- 22806562
OWN - NLM
STAT- MEDLINE
DCOM- 20130626
LR  - 20211021
IS  - 1432-198X (Electronic)
IS  - 0931-041X (Linking)
VI  - 27
IP  - 12
DP  - 2012 Dec
TI  - Living-donor transplantation after excision of unrecognized renal cancer 
      diagnosed after transplant.
PG  - 2319-21
LID - 10.1007/s00467-012-2255-0 [doi]
AB  - BACKGROUND: Published data on kidneys transplanted after resecting small renal 
      cancers during the transplantation surgery are very rare and, to the best of our 
      knowledge, no pediatric cases have been reported in the literature. 
      CASE-DIAGNOSIS/TREATMENT: Our patient was diagnosed with a bilateral Wilms tumor 
      when he was 15 months old. A total bilateral nephrectomy was required to control 
      the disease. Two years later, a human leukocyte antigen (HLA)-identical 
      living-donor transplant from his father was performed. A small mass in the 
      father's left kidney was diagnosed as an angiomyolipoma during the pretransplant 
      donor evaluation. During the surgery, the mass was excised and the kidney 
      implanted. One week later, the pathological study revealed the mass to be a clear 
      cell renal carcinoma. After joint discussion, the urologic and nephrologic teams 
      and the family decided to maintain the transplant, managing the patient with 
      monotherapy based on rapamycin and close ultrasound control. To date, 8 years 
      after transplantation, no signs of malignancy have been detected, and renal 
      function is normal. CONCLUSION: This is the first reported pediatric case of a 
      living-donor graft with a small renal carcinoma excised in the operating room. No 
      malignancy has been observed in 8 years of follow-up.
FAU - Melgosa Hijosa, Marta
AU  - Melgosa Hijosa M
AD  - Pediatric Nephrology Service, Hospital La Paz, P masculine Castellana n masculine 161, 28045, 
      Madrid, Spain. mmelgosa.hulp@salud.madrid.org
FAU - Alonso Melgar, Angel
AU  - Alonso Melgar A
FAU - Martinez Urrutia, Ma Jose
AU  - Martinez Urrutia MJ
FAU - Garcia Meseguer, Carmen
AU  - Garcia Meseguer C
FAU - Jaureguizar Monereo, Enrique
AU  - Jaureguizar Monereo E
FAU - Navarro Torres, Mercedes
AU  - Navarro Torres M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120718
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
SB  - IM
MH  - *Carcinoma, Renal Cell
MH  - Humans
MH  - Infant
MH  - *Kidney Neoplasms
MH  - *Kidney Transplantation
MH  - *Living Donors
MH  - Male
MH  - Nephrectomy
MH  - Wilms Tumor/pathology/surgery
EDAT- 2012/07/19 06:00
MHDA- 2013/06/28 06:00
CRDT- 2012/07/19 06:00
PHST- 2012/04/01 00:00 [received]
PHST- 2012/06/12 00:00 [accepted]
PHST- 2012/06/12 00:00 [revised]
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2013/06/28 06:00 [medline]
AID - 10.1007/s00467-012-2255-0 [doi]
PST - ppublish
SO  - Pediatr Nephrol. 2012 Dec;27(12):2319-21. doi: 10.1007/s00467-012-2255-0. Epub 
      2012 Jul 18.