PMID- 22806911
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20191210
IS  - 1699-5848 (Electronic)
IS  - 0213-3911 (Linking)
VI  - 27
IP  - 9
DP  - 2012 Sep
TI  - Histological changes in connective tissue of rat tails after bipolar 
      radiofrequency treatment.
PG  - 1231-7
LID - 10.14670/HH-27-1231 [doi]
AB  - Radiofrequency (RF) has been included in the techniques used in aesthetic 
      surgery/medicine. To date, no studies have performed a histological assessment of 
      changes in the tissue after application of bipolar radiofrequency (BRF) with low 
      energy and frequency. The aim of this study was to examine changes that are 
      produced in connective tissue, principally in the fibroblasts, following BRF 
      treatment. Four groups of rats received a different number of RF sessions (1, 2, 
      3 and 5). The following parameters were determined: the number of 
      fibroblasts/unit area (FA), the proliferation index (PI), the Heat shock Protein 
      47 index (HSPI) and the percentage of connective tissue (PC). For statistical 
      analysis, two subgroups (A and B) were made for the variables FA, PI and PC, and 
      another two subgroups (C and D) for the variable HSPI. Significant differences 
      for FA, PI and PC were observed between subgroups A and B, FA and PI having 
      higher values in A, while PC had higher values in B. The HSPI in subgroup C 
      showed significantly higher values than in D. Low energy and frequency BRF led to 
      an increase in the number, proliferation and biosynthetic activity of 
      fibroblasts. The resulting stress suffered by fibroblasts as a result of heat may 
      be associated with the phenomenon of hormesis.
FAU - Beltran-Frutos, E
AU  - Beltran-Frutos E
AD  - Department of Cell Biology and Histology, Aging Institute, Medical School, 
      Regional Campus of International Excellence Campus Mare Nostrum, University of 
      Murcia, Murcia, Spain.
FAU - Bernal-Manas, C M
AU  - Bernal-Manas CM
FAU - Navarro, S
AU  - Navarro S
FAU - Zuasti, A
AU  - Zuasti A
FAU - Ferrer, C
AU  - Ferrer C
FAU - Canteras, M
AU  - Canteras M
FAU - Seco-Rovira, V
AU  - Seco-Rovira V
FAU - Garcia-Collado, A J
AU  - Garcia-Collado AJ
FAU - Pastor, L M
AU  - Pastor LM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Spain
TA  - Histol Histopathol
JT  - Histology and histopathology
JID - 8609357
SB  - IM
MH  - Animals
MH  - Connective Tissue/*radiation effects
MH  - Electric Stimulation Therapy/methods
MH  - Female
MH  - Fibroblasts/*radiation effects
MH  - Hormesis
MH  - *Radiofrequency Therapy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tail
EDAT- 2012/07/19 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/07/19 06:00
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - 10.14670/HH-27-1231 [doi]
PST - ppublish
SO  - Histol Histopathol. 2012 Sep;27(9):1231-7. doi: 10.14670/HH-27-1231.