PMID- 22809749
OWN - NLM
STAT- MEDLINE
DCOM- 20130625
LR  - 20180816
IS  - 1872-7077 (Electronic)
IS  - 1382-6689 (Linking)
VI  - 34
IP  - 2
DP  - 2012 Sep
TI  - Synthesis of phenolic acid conjugated chitooligosaccharides and evaluation of 
      their antioxidant activity.
PG  - 519-527
LID - S1382-6689(12)00075-0 [pii]
LID - 10.1016/j.etap.2012.05.004 [doi]
AB  - In this study, eight kinds of phenolic acid conjugated chitooligosaccharides 
      (PA-c-COSs) with different substitution groups, including p-hydroxyl 
      hydroxybenzoic acid-c-COS (HBA-c-COS), p-coumaric acid-c-COS (PCA-c-COS), 
      3,4-dihydroxyl protocatechuic acid-c-COS (PTA-c-COS), caffeic acid-c-COS 
      (CFA-c-COS), 3-methoxyl-4-hydroxyl vanillic acid-c-COS (VNA-c-COS), ferulic 
      acid-c-COS (FRA-c-COS) and 3,5-dimethoxyl-4-hydroxy syringic acid-c-COS 
      (SRA-c-COS), sinapinic acid-c-COS (SNA-c-COS), were prepared by amide coupling 
      reaction. Their antioxidant properties were evaluated using several in vitro 
      models such as 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl (OH) and nitric 
      oxide (NO) radicals scavenging and reducing power assays. The structures of the 
      synthesized compounds were confirmed by UV, FT-IR and (1)H NMR data. CFA-c-COS 
      showed 81.6% and 89.8% scavenging against DPPH and NO radical formation, 
      respectively. CFA-c-COS also showed higher reducing power and hydroxyl radical 
      scavenging activity compared to those of other compounds. Hence, CFA-c-COS can be 
      a potential antioxidant compound.
CI  - Crown Copyright (c) 2012. Published by Elsevier B.V. All rights reserved.
FAU - Eom, Tae-Kil
AU  - Eom TK
AD  - Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, 
      Republic of Korea.
FAU - Senevirathne, Mahinda
AU  - Senevirathne M
AD  - Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, 
      Republic of Korea.
FAU - Kim, Se-Kwon
AU  - Kim SK
AD  - Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, 
      Republic of Korea; Department of Chemistry, Pukyong National University, Busan 
      608-737, Republic of Korea. Electronic address: sknkim@pknu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120529
PL  - Netherlands
TA  - Environ Toxicol Pharmacol
JT  - Environmental toxicology and pharmacology
JID - 9612020
RN  - 0 (Antioxidants)
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Hydroxybenzoates)
RN  - 0 (Oligosaccharides)
RN  - 0 (Picrates)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 9012-76-4 (Chitosan)
RN  - DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
RN  - I3P9R8317T (phenolic acid)
SB  - IM
MH  - Antioxidants/*chemistry
MH  - Biphenyl Compounds/chemistry
MH  - Chitosan/*chemistry
MH  - Hydroxybenzoates/*chemistry
MH  - Nitric Oxide/chemistry
MH  - Oligosaccharides/*chemistry
MH  - Picrates/chemistry
EDAT- 2012/07/20 06:00
MHDA- 2013/06/26 06:00
CRDT- 2012/07/20 06:00
PHST- 2011/11/04 00:00 [received]
PHST- 2012/05/16 00:00 [revised]
PHST- 2012/05/19 00:00 [accepted]
PHST- 2012/07/20 06:00 [entrez]
PHST- 2012/07/20 06:00 [pubmed]
PHST- 2013/06/26 06:00 [medline]
AID - S1382-6689(12)00075-0 [pii]
AID - 10.1016/j.etap.2012.05.004 [doi]
PST - ppublish
SO  - Environ Toxicol Pharmacol. 2012 Sep;34(2):519-527. doi: 
      10.1016/j.etap.2012.05.004. Epub 2012 May 29.