PMID- 22809777
OWN - NLM
STAT- MEDLINE
DCOM- 20130501
LR  - 20181201
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 47
DP  - 2012 Oct 15
TI  - Background exposure to persistent organic pollutants predicts stroke in the 
      elderly.
PG  - 115-20
LID - 10.1016/j.envint.2012.06.009 [doi]
AB  - Background exposure to persistent organic pollutants (POPs), lipophilic 
      xenobiotics that accumulate mainly in adipose tissue, has recently emerged as a 
      new risk factor for cardiovascular diseases. This prospective study was performed 
      to evaluate if plasma concentrations of selected POPs predict incident stroke 
      among the elderly. Twenty-one POPs (including 16 polychlorinated biphenyl (PCB) 
      congeners, 3 organochlorine (OC) pesticides, 1 brominated diphenyl ether (BDE), 
      and 1 dioxin) were measured in plasma collected at baseline in 898 participants 
      aged 70 years of the Prospective Investigation of the Vasculature in Uppsala 
      Seniors (PIVUS). Stroke diagnosis was validated by hospital records. During the 
      five year follow-up, 35 subjects developed hospital-treated stroke. After 
      adjusting for known stroke risk factors, most PCBs with 4, 5, or 6 chlorine 
      atoms, p,p'-DDE, trans-nonachlor, and octachlorodibenzo-p-dioxin significantly 
      predicted the risk of stroke. Across quartiles of summary measures of PCBs and OC 
      pesticides, the adjusted ORs were 1.0, 0.8 (95% confidence interval: 0.2-2.5), 
      1.2 (0.4-3.4), and 2.1 (0.7-6.2) for PCBs and 1.0, 1.2 (0.3-4.2), 2.3 (0.7-6.9), 
      and 3.0 (1.0-9.4) for OC pesticides (P for trend=0.11 and 0.03, respectively). 
      The adjusted ORs among participants >/= 90th percentile of the summary measures 
      were 5.5 (1.7-18.1) for PCBs and 4.0 (1.1-14.6) for OC pesticides; corresponding 
      ORs for those >/= 95th percentile were 7.8 (2.1-29.6) and 9.5 (2.3-38.9). 
      Background exposure to POPs may play an important role in development or 
      progression of stroke in the elderly.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Lee, Duk-Hee
AU  - Lee DH
AD  - Department of Preventative Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Republic of Korea.
FAU - Lind, P Monica
AU  - Lind PM
FAU - Jacobs, David R Jr
AU  - Jacobs DR Jr
FAU - Salihovic, Samira
AU  - Salihovic S
FAU - van Bavel, Bert
AU  - van Bavel B
FAU - Lind, Lars
AU  - Lind L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120717
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 3734-49-4 (nonachlor)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - YW59P10266 (octachlorodibenzo-4-dioxin)
SB  - IM
MH  - Aged
MH  - Dichlorodiphenyl Dichloroethylene/blood
MH  - Dioxins/blood
MH  - Environmental Exposure/*analysis/statistics & numerical data
MH  - Environmental Pollutants/*blood
MH  - Environmental Pollution/statistics & numerical data
MH  - Female
MH  - Halogenated Diphenyl Ethers/blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/blood
MH  - Male
MH  - Pesticides/blood
MH  - Polychlorinated Biphenyls/blood
MH  - Polychlorinated Dibenzodioxins/blood
MH  - Stroke/*epidemiology
EDAT- 2012/07/20 06:00
MHDA- 2013/05/02 06:00
CRDT- 2012/07/20 06:00
PHST- 2011/11/15 00:00 [received]
PHST- 2012/05/31 00:00 [revised]
PHST- 2012/06/16 00:00 [accepted]
PHST- 2012/07/20 06:00 [entrez]
PHST- 2012/07/20 06:00 [pubmed]
PHST- 2013/05/02 06:00 [medline]
AID - S0160-4120(12)00136-5 [pii]
AID - 10.1016/j.envint.2012.06.009 [doi]
PST - ppublish
SO  - Environ Int. 2012 Oct 15;47:115-20. doi: 10.1016/j.envint.2012.06.009. Epub 2012 
      Jul 17.