PMID- 22809875
OWN - NLM
STAT- MEDLINE
DCOM- 20121116
LR  - 20120903
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 251
IP  - 1-2
DP  - 2012 Oct 15
TI  - Antibodies to N-methyl-D-aspartate glutamate receptors in Creutzfeldt-Jakob 
      disease patients.
PG  - 90-3
LID - 10.1016/j.jneuroim.2012.06.010 [doi]
AB  - Psychiatric symptom can be a prominent feature early in Creutzfeldt-Jakob disease 
      (CJD), which is also common in autoantibody-mediated limbic encephalitis. We 
      hypothesized that anti-neuronal autoantibodies, especially those against 
      N-methyl-D-aspartate glutamate receptors (NMDAR), can also be associated with 
      CJD. Thirteen patients with CJD and 13 patients with limbic encephalitis were 
      enrolled. Immunohistochemistry demonstrated that serum of CJD patients reacted 
      with neuronal components of the rat hippocampus, indicating that those samples 
      contained anti-neuronal antibodies. Enzyme-linked immunosorbent assay revealed 
      that titers of antibodies against peptides of GluN2B subunit of NMDAR were 
      significantly elevated in the serum and cerebrospinal fluid of CJD patients.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Fujita, Koji
AU  - Fujita K
AD  - Department of Clinical Neuroscience, The University of Tokushima Graduate School, 
      3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan. kof@clin.med.tokushima-u.ac.jp
FAU - Yuasa, Tatsuhiko
AU  - Yuasa T
FAU - Takahashi, Yukitoshi
AU  - Takahashi Y
FAU - Tanaka, Keiko
AU  - Tanaka K
FAU - Sako, Wataru
AU  - Sako W
FAU - Koizumi, Hidetaka
AU  - Koizumi H
FAU - Iwasaki, Yasushi
AU  - Iwasaki Y
FAU - Yoshida, Mari
AU  - Yoshida M
FAU - Izumi, Yuishin
AU  - Izumi Y
FAU - Kaji, Ryuji
AU  - Kaji R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120717
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Autoantibodies)
RN  - 0 (NR2B NMDA receptor)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Animals
MH  - Autoantibodies/blood/cerebrospinal fluid/*immunology
MH  - Creutzfeldt-Jakob Syndrome/blood/cerebrospinal fluid/*immunology
MH  - Female
MH  - Hippocampus/immunology/metabolism
MH  - Humans
MH  - Limbic Encephalitis/blood/immunology/metabolism
MH  - Male
MH  - Middle Aged
MH  - Rats
MH  - Receptors, N-Methyl-D-Aspartate/blood/*immunology/metabolism
EDAT- 2012/07/20 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/20 06:00
PHST- 2012/03/16 00:00 [received]
PHST- 2012/06/25 00:00 [revised]
PHST- 2012/06/29 00:00 [accepted]
PHST- 2012/07/20 06:00 [entrez]
PHST- 2012/07/20 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0165-5728(12)00211-1 [pii]
AID - 10.1016/j.jneuroim.2012.06.010 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2012 Oct 15;251(1-2):90-3. doi: 10.1016/j.jneuroim.2012.06.010. 
      Epub 2012 Jul 17.