PMID- 22811357
OWN - NLM
STAT- MEDLINE
DCOM- 20130207
LR  - 20211021
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Print)
IS  - 0887-8013 (Linking)
VI  - 26
IP  - 4
DP  - 2012 Jul
TI  - Risk of overestimation of kidney function using GFR-estimating equations in 
      patients with low inulin clearance.
PG  - 248-53
LID - 10.1002/jcla.21513 [doi]
AB  - BACKGROUND: Accurate estimation of the glomerular filtration rate (GFR) is very 
      important in clinical practice. Although renal inulin clearance (Cin) is the gold 
      standard for measuring GFR, the procedure for Cin measurement is complicated. Use 
      of GFR-estimating equations has been increasing recently due to their simplicity. 
      The objectives of the present study are to analyze the correlation between Cin 
      and other GFR-estimating parameters and to investigate their clinical usefulness 
      and limitation. METHODS: Seventy-two Japanese patients were enrolled in this 
      study. Cin was measured by the continuous infusion method. Serum creatinine 
      (s-Cr), cystatin C, uric acid (UA), and hemoglobin (Hb) were measured. The 
      Japanese formula of estimated GFR (eGFR) was as follows: eGFR (ml/min/1.73m(2) ) 
      = 194 x s-Cr(-1.094) x Age(-0.287) x 0.739 (if female). The endogenous creatinine 
      clearance test was also performed. RESULTS: Levels of Cin were highly correlated 
      with those of endogenous creatinine clearance (Ccr) (R(2) = 0.7585) and eGFR 
      (R(2) = 0.5659). However, patients with lower Cin showed unexpectedly elevated 
      levels of endogenous Ccr and eGFR. Moreover, the levels of eGFR tended to be 
      unexpectedly increased in patients with low body surface area. CONCLUSION: 
      Although GFR-estimating equations are useful for estimating GFR accurately, they 
      pose a risk of overestimation of kidney function in patients with decreased GFRor 
      a poor physique.
CI  - (c) 2012 Wiley Periodicals, Inc.
FAU - Nakata, Junichiro
AU  - Nakata J
AD  - Division of Nephrology, Department of Internal Medicine, Juntendo University 
      Faculty of Medicine, Tokyo, Japan.
FAU - Ohsawa, Isao
AU  - Ohsawa I
FAU - Onda, Kisara
AU  - Onda K
FAU - Tanimoto, Mitsuo
AU  - Tanimoto M
FAU - Kusaba, Gaku
AU  - Kusaba G
FAU - Takeda, Yukihiko
AU  - Takeda Y
FAU - Kobayashi, Noriyoshi
AU  - Kobayashi N
FAU - Asanuma, Katsuhiko
AU  - Asanuma K
FAU - Tanaka, Yuichi
AU  - Tanaka Y
FAU - Sato, Michiko
AU  - Sato M
FAU - Inami, Yuko
AU  - Inami Y
FAU - Suzuki, Hitoshi
AU  - Suzuki H
FAU - Suzuki, Hiyori
AU  - Suzuki H
FAU - Masuda, Atsumi
AU  - Masuda A
FAU - Nonaka, Kanae
AU  - Nonaka K
FAU - Sasaki, Yu
AU  - Sasaki Y
FAU - Hisada, Atsuko
AU  - Hisada A
FAU - Hamada, Chieko
AU  - Hamada C
FAU - Horikoshi, Satoshi
AU  - Horikoshi S
FAU - Tomino, Yasuhiko
AU  - Tomino Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
RN  - 0 (CST3 protein, human)
RN  - 0 (Cystatin C)
RN  - 9005-80-5 (Inulin)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Creatinine/blood/urine
MH  - Cystatin C/blood
MH  - Data Interpretation, Statistical
MH  - Female
MH  - Glomerular Filtration Rate/*physiology
MH  - Humans
MH  - Inulin/*blood/*urine
MH  - Kidney Function Tests/*standards
MH  - Male
MH  - Middle Aged
PMC - PMC6807624
EDAT- 2012/07/20 06:00
MHDA- 2013/02/08 06:00
PMCR- 2012/07/18
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2012/07/20 06:00 [pubmed]
PHST- 2013/02/08 06:00 [medline]
PHST- 2012/07/18 00:00 [pmc-release]
AID - JCLA21513 [pii]
AID - 10.1002/jcla.21513 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2012 Jul;26(4):248-53. doi: 10.1002/jcla.21513.