PMID- 22811904
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 2090-2115 (Electronic)
IS  - 2090-2107 (Print)
IS  - 2090-2107 (Linking)
VI  - 2012
DP  - 2012
TI  - Extracellular matrix proteins modulate antimigratory and apoptotic effects of 
      Doxorubicin.
PG  - 268681
LID - 10.1155/2012/268681 [doi]
LID - 268681
AB  - Anticancer drug resistance is a multifactorial process that includes acquired and 
      de novo drug resistances. Acquired resistance develops during treatment, while de 
      novo resistance is the primary way for tumor cells to escape chemotherapy. Tumor 
      microenvironment has been recently shown to be one of the important factors 
      contributing to de novo resistance and called environment-mediated drug 
      resistance (EMDR). Two forms of EMDR have been described: soluble factor-mediated 
      drug resistance (SFM-DR) and cell adhesion-mediated drug resistance (CAM-DR). 
      Anthracyclines, among the most potent chemotherapeutic agents, are widely used in 
      clinics against hematopoietic and solid tumors. Their main mechanism of action 
      relies on the inhibition of topoisomerase I and/or II and the induction of 
      apoptosis. Beyond this well-known antitumor activity, it has been recently 
      demonstrated that anthracyclines may display potent anti-invasive effects when 
      used at subtoxic concentrations. In this paper, we will describe two particular 
      modes of EMDR by which microenvironment may influence tumor-cell response to one 
      of these anthracyclines, doxorubicin. The first one considers the influence of 
      type I collagen on the antimigratory effect of doxorubicin (CAM-DR). The second 
      considers the protection of tumor cells by thrombospondin-I against 
      doxorubicin-induced apoptosis (SFM-DR).
FAU - Said, Georges
AU  - Said G
AD  - UFR Pharmacie, FRE CNRS/URCA no. 3481, Universite de Reims Champagne-Ardenne, 
      51096 Reims, Cedex, France.
FAU - Guilbert, Marie
AU  - Guilbert M
FAU - Morjani, Hamid
AU  - Morjani H
FAU - Garnotel, Roselyne
AU  - Garnotel R
FAU - Jeannesson, Pierre
AU  - Jeannesson P
FAU - El Btaouri, Hassan
AU  - El Btaouri H
LA  - eng
PT  - Journal Article
DEP - 20120701
PL  - Egypt
TA  - Chemother Res Pract
JT  - Chemotherapy research and practice
JID - 101566606
PMC - PMC3395309
EDAT- 2012/07/20 06:00
MHDA- 2012/07/20 06:01
PMCR- 2012/07/01
CRDT- 2012/07/20 06:00
PHST- 2012/02/03 00:00 [received]
PHST- 2012/04/30 00:00 [accepted]
PHST- 2012/07/20 06:00 [entrez]
PHST- 2012/07/20 06:00 [pubmed]
PHST- 2012/07/20 06:01 [medline]
PHST- 2012/07/01 00:00 [pmc-release]
AID - 10.1155/2012/268681 [doi]
PST - ppublish
SO  - Chemother Res Pract. 2012;2012:268681. doi: 10.1155/2012/268681. Epub 2012 Jul 1.