PMID- 22813992 OWN - NLM STAT- MEDLINE DCOM- 20130314 LR - 20220316 IS - 1873-7528 (Electronic) IS - 0149-7634 (Linking) VI - 36 IP - 9 DP - 2012 Oct TI - Effect of BDNF val(66)met polymorphism on declarative memory and its neural substrate: a meta-analysis. PG - 2165-77 LID - S0149-7634(12)00100-5 [pii] LID - 10.1016/j.neubiorev.2012.07.002 [doi] AB - Brain derived neurotrophic factor (BDNF) is a critical component of the molecular mechanism of memory formation. Variation in the BDNF gene, particularly the rs6265 (val(66)met) single nucleotide polymorphism (SNP), has been linked to variability in human memory performance and to both the structure and physiological response of the hippocampus, which plays a central role in memory processing. However, these effects have not been consistently reported, which may reflect the modest size of the samples studied to date. Employing a meta-analytic approach, we examined the effect of the BDNF val(66)met polymorphism on human memory (5922 subjects) and hippocampal structure (2985 subjects) and physiology (362 subjects). Our results suggest that variations in the rs6265 SNP of the BDNF gene have a significant effect on memory performance, and on both the structure and physiology of the hippocampus, with carriers of the met allele being adversely affected. These results underscore the role of BDNF in moderating variability between individuals in human memory performance and in mediating some of the neurocognitive impairments underlying neuropsychiatric disorders. CI - Copyright (c) 2012 Elsevier Ltd. All rights reserved. FAU - Kambeitz, Joseph P AU - Kambeitz JP AD - Department of Psychosis Studies, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK. joseph.kambeitz@kcl.ac.uk FAU - Bhattacharyya, Sagnik AU - Bhattacharyya S FAU - Kambeitz-Ilankovic, Lana M AU - Kambeitz-Ilankovic LM FAU - Valli, Isabel AU - Valli I FAU - Collier, David A AU - Collier DA FAU - McGuire, Philip AU - McGuire P LA - eng GR - G0601437/MRC_/Medical Research Council/United Kingdom GR - NIHR-CS-011-001/DH_/Department of Health/United Kingdom GR - G0501775/MRC_/Medical Research Council/United Kingdom PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't DEP - 20120716 PL - United States TA - Neurosci Biobehav Rev JT - Neuroscience and biobehavioral reviews JID - 7806090 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM CIN - Neurosci Biobehav Rev. 2013 May;37(4):739-41. PMID: 23348002 MH - Alleles MH - Brain-Derived Neurotrophic Factor/*genetics MH - Genotype MH - Hippocampus/*physiology MH - Humans MH - Memory/*physiology MH - Neuropsychological Tests MH - *Polymorphism, Single Nucleotide EDAT- 2012/07/21 06:00 MHDA- 2013/03/15 06:00 CRDT- 2012/07/21 06:00 PHST- 2011/09/08 00:00 [received] PHST- 2012/03/16 00:00 [revised] PHST- 2012/07/07 00:00 [accepted] PHST- 2012/07/21 06:00 [entrez] PHST- 2012/07/21 06:00 [pubmed] PHST- 2013/03/15 06:00 [medline] AID - S0149-7634(12)00100-5 [pii] AID - 10.1016/j.neubiorev.2012.07.002 [doi] PST - ppublish SO - Neurosci Biobehav Rev. 2012 Oct;36(9):2165-77. doi: 10.1016/j.neubiorev.2012.07.002. Epub 2012 Jul 16.