PMID- 22813995
OWN - NLM
STAT- MEDLINE
DCOM- 20130124
LR  - 20230113
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 222
DP  - 2012 Oct 11
TI  - Effects of voluntary running on plasma levels of neurotrophins, hippocampal cell 
      proliferation and learning and memory in stressed rats.
PG  - 289-301
LID - 10.1016/j.neuroscience.2012.07.019 [doi]
AB  - Previous studies have shown that a 2-week treatment with 40 mg/kg corticosterone 
      (CORT) in rats suppresses hippocampal neurogenesis and decreases hippocampal 
      brain-derived neurotrophic factor (BDNF) levels and impairs spatial learning, all 
      of which could be counteracted by voluntary wheel running. BDNF and insulin-like 
      growth factor (IGF-1) have been suggested to mediate physical exercise-enhanced 
      hippocampal neurogenesis and cognition. Here we examined whether such 
      running-elicited benefits were accompanied by corresponding changes of peripheral 
      BDNF and IGF-1 levels in a rat model of stress. We examined the effects of acute 
      (5 days) and chronic (4 weeks) treatment with CORT and/or wheel running on (1) 
      hippocampal cell proliferation, (2) spatial learning and memory and (3) plasma 
      levels of BDNF and IGF-1. Acute CORT treatment improved spatial learning without 
      altered cell proliferation compared to vehicle treatment. Acute CORT-treated 
      non-runners showed an increased trend in plasma BDNF levels together with a 
      significant increase in hippocampal BDNF levels. Acute running showed no effect 
      on cognition, cell proliferation and peripheral BDNF and IGF-1 levels. 
      Conversely, chronic CORT treatment in non-runners significantly impaired spatial 
      learning and suppressed cell proliferation in association with a decreased trend 
      in plasma BDNF level and a significant increase in hippocampal BDNF levels. 
      Running counteracted cognitive deficit and restored hippocampal cell 
      proliferation following chronic CORT treatment; but without corresponding changes 
      in plasma BDNF and IGF-1 levels. The results suggest that the beneficial effects 
      of acute stress on cognitive improvement may be mediated by BDNF-enhanced 
      synaptic plasticity that is hippocampal cell proliferation-independent, whereas 
      chronic stress may impair cognition by decreasing hippocampal cell proliferation 
      and BDNF levels. Furthermore, the results indicate a trend in changes of plasma 
      BDNF levels associated with a significant alteration in hippocampal levels, 
      suggesting that treatment with running/CORT for 4 weeks may induce a change in 
      central levels of hippocampal BDNF level, which may not lead to a significant 
      change in peripheral levels.
CI  - Copyright (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Yau, S-Y
AU  - Yau SY
AD  - Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong 
      Kong, Pokfulam, Hong Kong Special Administrative Region.
FAU - Lau, B W-M
AU  - Lau BW
FAU - Zhang, E-D
AU  - Zhang ED
FAU - Lee, J C-D
AU  - Lee JC
FAU - Li, A
AU  - Li A
FAU - Lee, T M C
AU  - Lee TM
FAU - Ching, Y-P
AU  - Ching YP
FAU - Xu, A-M
AU  - Xu AM
FAU - So, K-F
AU  - So KF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120717
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - G34N38R2N1 (Bromodeoxyuridine)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Animals
MH  - Body Weight/physiology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Bromodeoxyuridine
MH  - Cell Differentiation/physiology
MH  - *Cell Proliferation
MH  - Fluorescent Antibody Technique
MH  - Hippocampus/*cytology
MH  - Hydrocortisone/metabolism
MH  - Immunohistochemistry
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Learning/*physiology
MH  - Male
MH  - Maze Learning/physiology
MH  - Memory/*physiology
MH  - Nerve Growth Factors/*blood
MH  - Organ Size/physiology
MH  - Physical Conditioning, Animal/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Running/*psychology
MH  - Stress, Psychological/blood/*psychology
MH  - Taste/drug effects/physiology
EDAT- 2012/07/21 06:00
MHDA- 2013/01/25 06:00
CRDT- 2012/07/21 06:00
PHST- 2012/03/02 00:00 [received]
PHST- 2012/07/06 00:00 [revised]
PHST- 2012/07/08 00:00 [accepted]
PHST- 2012/07/21 06:00 [entrez]
PHST- 2012/07/21 06:00 [pubmed]
PHST- 2013/01/25 06:00 [medline]
AID - S0306-4522(12)00726-9 [pii]
AID - 10.1016/j.neuroscience.2012.07.019 [doi]
PST - ppublish
SO  - Neuroscience. 2012 Oct 11;222:289-301. doi: 10.1016/j.neuroscience.2012.07.019. 
      Epub 2012 Jul 17.