PMID- 22817136
OWN - NLM
STAT- MEDLINE
DCOM- 20130620
LR  - 20131121
IS  - 1556-7125 (Electronic)
IS  - 1535-3141 (Linking)
VI  - 9
IP  - 8
DP  - 2012 Aug
TI  - Anaphylaxis induced by ingestion of raw garlic.
PG  - 773-5
LID - 10.1089/fpd.2012.1133 [doi]
AB  - Patients allergic to garlic often present dermatitis, rhinitis, asthma, and 
      urticaria after ingestion of garlic, contact with garlic, or exposure to garlic 
      dust. Garlic-related anaphylaxis is rare, and the impact of heating on garlic 
      allergens is not very clear. We report a case of anaphylaxis induced by ingestion 
      of raw rather than cooked garlic with manifestations different from previous 
      reports, and we hypothesized that heating could reduce the allergenicity of 
      garlic. Serum total immunoglobulin E (IgE) and specific IgE were tested using the 
      Phadia CAP System FEIA (Phadia, Uppsala, Sweden). Protein extracts from raw and 
      cooked garlic were analyzed by sodium dodecylsulfate-polyacrylamide gel 
      electrophoresis (SDS-PAGE) and Western blot. Serum-specific IgE for garlic was 
      8.16 kUA/L. IgE banding proteins could only be detected in raw garlic extract, 
      because allergens in garlic were mostly degraded into small fragments after 
      heating, as shown in SDS-PAGE profile. In conclusion, raw garlic could induce 
      life-threatening anaphylaxis. However, most of its allergens are heat labile, and 
      patients allergic to garlic might tolerate the cooked one well.
FAU - Ma, Shikun
AU  - Ma S
AD  - Department of Allergy, Peking Union Medical College Hospital, Peking Union 
      Medical College & Chinese Academy of Medical Sciences, Beijing, China.
FAU - Yin, Jia
AU  - Yin J
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120720
PL  - United States
TA  - Foodborne Pathog Dis
JT  - Foodborne pathogens and disease
JID - 101120121
RN  - 0 (Allergens)
RN  - 368GB5141J (Sodium Dodecyl Sulfate)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Allergens/analysis
MH  - Anaphylaxis/diagnosis/*immunology
MH  - Blotting, Western
MH  - Cooking
MH  - Electrophoresis, Polyacrylamide Gel
MH  - Food Hypersensitivity/immunology/*physiopathology
MH  - Garlic/*adverse effects/chemistry
MH  - Humans
MH  - Immunoglobulin E/blood/immunology
MH  - Male
MH  - Sodium Dodecyl Sulfate/metabolism
EDAT- 2012/07/24 06:00
MHDA- 2013/06/21 06:00
CRDT- 2012/07/24 06:00
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2013/06/21 06:00 [medline]
AID - 10.1089/fpd.2012.1133 [doi]
PST - ppublish
SO  - Foodborne Pathog Dis. 2012 Aug;9(8):773-5. doi: 10.1089/fpd.2012.1133. Epub 2012 
      Jul 20.