PMID- 22818527
OWN - NLM
STAT- MEDLINE
DCOM- 20130807
LR  - 20121225
IS  - 1873-5126 (Electronic)
IS  - 1353-8020 (Linking)
VI  - 19
IP  - 1
DP  - 2013 Jan
TI  - Impaired pain processing in Parkinson's disease and its relative association with 
      the sense of smell.
PG  - 43-6
LID - S1353-8020(12)00258-1 [pii]
LID - 10.1016/j.parkreldis.2012.06.020 [doi]
AB  - BACKGROUND AND PURPOSE: Many non-motor symptoms are associated with Parkinson's 
      disease (PD). Of these, pain and olfactory disturbance tend to be common premotor 
      symptoms. PD has been shown to exhibit abnormal central pain processing, although 
      underlying mechanisms are not yet fully understood. In order to investigate this 
      further, we assessed PD patients by specific Adelta stimulation with intra-epidermal 
      needle electrode and determined olfactory function. METHODS: Forty-two patients 
      (18 males and 24 females) with PD and 17 healthy control subjects (8 males and 9 
      females) were studied. A thin needle electrode was used to stimulate epidermal Adelta 
      fibers, and somatosensory evoked potentials (SEPs) recorded at the vertex. 
      Olfactory function was evaluated using the Odor Stick Identification Test for 
      Japanese (OSIT-J) and its relationship with pain-related SEPs was investigated. 
      RESULTS: There were no significant differences in N1 latencies or P1 latencies 
      although N1/P1 peak-to-peak amplitudes were significantly lower (p < 0.01) in PD 
      patients than in control subjects. In PD patients, there were significant 
      correlations between N1/P1 amplitudes and disease duration (r = -0.35, p < 0.05), 
      Hoehn-Yahr stage (r = -0.38, p < 0.05) and UPDRS part III (r = -0.42, p < 0.01). 
      Furthermore, the OSIT-J scores correlated with SEP amplitude (r = 0.41, p < 
      0.01). CONCLUSION: Pain processing in PD patients was impaired under specific 
      nociceptive stimulation of Adelta fibers and significant correlation with smell 
      dysfunction was detected. We suggest that this mechanism may involve the limbic 
      system during PD pathology.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Hara, Takashi
AU  - Hara T
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
FAU - Hirayama, Masaaki
AU  - Hirayama M
FAU - Mizutani, Yasuaki
AU  - Mizutani Y
FAU - Hama, Tetsuo
AU  - Hama T
FAU - Hori, Norio
AU  - Hori N
FAU - Nakamura, Tomohiko
AU  - Nakamura T
FAU - Kato, Shigenori
AU  - Kato S
FAU - Watanabe, Hirohisa
AU  - Watanabe H
FAU - Sobue, Gen
AU  - Sobue G
LA  - eng
PT  - Journal Article
DEP - 20120717
PL  - England
TA  - Parkinsonism Relat Disord
JT  - Parkinsonism & related disorders
JID - 9513583
SB  - IM
MH  - Aged
MH  - Evoked Potentials, Somatosensory/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Olfaction Disorders/complications/*physiopathology
MH  - *Pain/complications
MH  - Pain Measurement/methods
MH  - Parkinson Disease/complications/*physiopathology
MH  - Smell/*physiology
EDAT- 2012/07/24 06:00
MHDA- 2013/08/08 06:00
CRDT- 2012/07/24 06:00
PHST- 2012/03/01 00:00 [received]
PHST- 2012/06/25 00:00 [revised]
PHST- 2012/06/26 00:00 [accepted]
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2013/08/08 06:00 [medline]
AID - S1353-8020(12)00258-1 [pii]
AID - 10.1016/j.parkreldis.2012.06.020 [doi]
PST - ppublish
SO  - Parkinsonism Relat Disord. 2013 Jan;19(1):43-6. doi: 
      10.1016/j.parkreldis.2012.06.020. Epub 2012 Jul 17.