PMID- 22820234
OWN - NLM
STAT- MEDLINE
DCOM- 20130123
LR  - 20131121
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 235
IP  - 1
DP  - 2012 Nov 1
TI  - Curcumin produces antidepressant effects via activating MAPK/ERK-dependent 
      brain-derived neurotrophic factor expression in the amygdala of mice.
PG  - 67-72
LID - 10.1016/j.bbr.2012.07.019 [doi]
AB  - The potential antidepressant effects of curcumin have been demonstrated in 
      various animal models of depression, however, there is little information 
      regarding the site and mechanisms of curcumin in promoting antidepressant 
      effects. The present study attempts to explore the mechanisms underlying the 
      antidepressant-like action of curcumin by measuring the contents of brain derived 
      neurotrophic factor (BDNF) in the amygdala of animal model of depression. The 
      results showed that treatment with curcumin (40 mg/kg, i.p.) significantly 
      reduced depressive-like behaviors of mice in the forced swim test. Chronic 
      administration of curcumin (40 mg/kg, i.p., 21 days) increased BDNF protein 
      levels in the amygdala and this enhancement was suppressed by pretreatment with 
      the extracellular signal-regulated kinase (ERK) inhibitor SL327. Additionally, 
      the increased levels of ERK phosphoryation in the amygdala by curcumin were 
      blocked by the ERK inhibitor, and inhibition of this kinase prevented the 
      antidepressant effects of curcumin. All of these effects of curcumin, were 
      essentially identical to that observed with the clinical antidepressant, 
      fluoxetine. These results suggest that the antidepressant-like effects of 
      curcumin in the forced swim test are mediated, at least in part, by an 
      ERK-regulated increase of BDNF expression in the amygdala of mice.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Zhang, Lin
AU  - Zhang L
AD  - Department of Physiology, Shandong University, School of Medicine, Wenhuaxilu 
      Road, Jinan, Shandong Province, 250012, PR China.
FAU - Xu, Tianyuan
AU  - Xu T
FAU - Wang, Shuang
AU  - Wang S
FAU - Yu, Lanqing
AU  - Yu L
FAU - Liu, Dexiang
AU  - Liu D
FAU - Zhan, Renzhi
AU  - Zhan R
FAU - Yu, Shu Yan
AU  - Yu SY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120720
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (SL 327)
RN  - 3739OQ10IJ (Aminoacetonitrile)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Aminoacetonitrile/analogs & derivatives/pharmacology
MH  - Amygdala/*metabolism
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - Curcumin/*pharmacology/therapeutic use
MH  - Depression/drug therapy
MH  - Disease Models, Animal
MH  - Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors/*metabolism
MH  - Gene Expression Regulation/drug effects
MH  - MAP Kinase Signaling System/*drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Phosphorylation/drug effects
EDAT- 2012/07/24 06:00
MHDA- 2013/01/24 06:00
CRDT- 2012/07/24 06:00
PHST- 2012/06/19 00:00 [received]
PHST- 2012/07/09 00:00 [revised]
PHST- 2012/07/13 00:00 [accepted]
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2013/01/24 06:00 [medline]
AID - S0166-4328(12)00475-5 [pii]
AID - 10.1016/j.bbr.2012.07.019 [doi]
PST - ppublish
SO  - Behav Brain Res. 2012 Nov 1;235(1):67-72. doi: 10.1016/j.bbr.2012.07.019. Epub 
      2012 Jul 20.