PMID- 22820627
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20220331
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 73
IP  - 9
DP  - 2012 Sep
TI  - Human leukocyte antigen-G (HLA-G) expression in cervical cancer lesions is 
      associated with disease progression.
PG  - 946-9
LID - 10.1016/j.humimm.2012.07.041 [doi]
AB  - The immunotolerant human leukocyte antigen (HLA)-G has direct inhibitory effects 
      on natural killer cells, dendritic cells, T cells and can indirectly induce 
      tolerant regulatory cells. The significance of the aberrant HLA-G expression in 
      malignant contexts has been intensively investigated. In the current study, HLA-G 
      expression in 22 normal cervical tissues, 14 cervical intraepithelial neoplasia 
      (CIN) patients and 129 patients with squamous cell cervical cancer were examined 
      using immunohistochemistry. The association of HLA-G expression with disease 
      progression was calculated with the Pearson Chi-square test. It was found that 
      HLA-G expression was absent in normal cervical tissues, and that HLA-G expression 
      was increased from patients with CIN III (35.7%, 4/14) to patients with cervical 
      cancer (62.8%, 81/129). Among the cervical cancer patients, HLA-G expression in 
      FIGO stage I, II, and stage III+IV was 53.6% (45/84), 76.3% (29/38), and 100.0% 
      (7/7), respectively. Taken together, our findings indicated that HLA-G expression 
      was associated with the disease progression in patients with cervical cancer.
CI  - Copyright (c) 2012 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Li, Xiang-Juan
AU  - Li XJ
AD  - Department of Obstetrics and Gynecology, Huangyan Hospital, Wenzhou Medical 
      College, Huangyan, Zhejiang, China.
FAU - Zhang, Xia
AU  - Zhang X
FAU - Lin, Aifen
AU  - Lin A
FAU - Ruan, Yan-Yun
AU  - Ruan YY
FAU - Yan, Wei-Hua
AU  - Yan WH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120720
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Disease Progression
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - HLA-G Antigens/genetics/*metabolism
MH  - Humans
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Uterine Cervical Neoplasms/genetics/*metabolism/pathology
MH  - Young Adult
EDAT- 2012/07/24 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/07/24 06:00
PHST- 2012/03/05 00:00 [received]
PHST- 2012/04/24 00:00 [revised]
PHST- 2012/07/11 00:00 [accepted]
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
AID - S0198-8859(12)00206-6 [pii]
AID - 10.1016/j.humimm.2012.07.041 [doi]
PST - ppublish
SO  - Hum Immunol. 2012 Sep;73(9):946-9. doi: 10.1016/j.humimm.2012.07.041. Epub 2012 
      Jul 20.