PMID- 22820916
OWN - NLM
STAT- MEDLINE
DCOM- 20130125
LR  - 20191210
IS  - 1538-943X (Electronic)
IS  - 1058-2916 (Linking)
VI  - 58
IP  - 5
DP  - 2012 Sep-Oct
TI  - Development of endovascular vibrating polymer actuator probe for mechanical 
      thrombolysis: in vivo study.
PG  - 503-8
LID - 10.1097/MAT.0b013e31825f341c [doi]
AB  - In this study, we propose a new method for the enhancement of intraarterial 
      thrombolysis by use of an endovascular vibrating polymer actuator probe (VPAP), 
      which is fabricated from an ionic polymer metal composite (IPMC) actuator. The 
      endovascular VPAP was fabricated by combining 0.8 x 0.8 x 10 mm3 IPMC samples, 
      0.22 mm x 50 cm copper wires, and 40 cm of Teflon tube. The purpose of this study 
      was to evaluate the thrombolysis efficiency of an endovascular VPAP in a dog 
      model. Both renal arteries of the enrolled dogs (n = 5) were used in the current 
      study. A distal portion of the renal artery in a mongrel dog was occluded by a 
      blood clot from autologous venous whole blood. Intraarterial thrombolysis was 
      performed by use of a VPAP without the actuation force (control group), by a 
      VPAP-only (VPAP-only group), or with a combination of recombinant tissue 
      plasminogen activator (rtPA) and a VPAP (VPAP + rtPA group). The thrombolysis 
      efficiency was evaluated by the modified Thrombolysis in Myocardial Infarction 
      (TIMI) grading system based on the consensus between two radiologists. The 
      grading scales were compared according to each intraarterial thrombolysis method. 
      The VPAP + rtPA and VPAP-only groups showed a significantly higher thrombolysis 
      efficiency than did the control group (p < 0.05). The VPAP-only group also showed 
      a significantly higher thrombolysis efficiency than did the control group (p < 
      0.05). The VPAP+ rtPA group showed a significantly higher thrombolysis efficiency 
      than did the VPAP-only group (p < 0.05). The use of an endovascular VPAP was a 
      feasible and useful method for intraarterial thrombolysis, and it enhanced the 
      thrombolysis efficiency when combined with the thrombolytic agent rtPA.
FAU - Jung, Seung Chai
AU  - Jung SC
AD  - Department of Radiology, Seoul National University College of Medicine, Seoul, 
      Korea.
FAU - Yoon, Bye-Ri
AU  - Yoon BR
FAU - Oh, Jin Sun
AU  - Oh JS
FAU - Choi, Seung Hong
AU  - Choi SH
FAU - Han, Moon Hee
AU  - Han MH
FAU - Lee, Jang Yeol
AU  - Lee JY
FAU - Cho, Hye Rim
AU  - Cho HR
FAU - Rhee, Kyehan
AU  - Rhee K
FAU - Jho, Jae Young
AU  - Jho JY
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polymers)
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials
MH  - Dogs
MH  - Equipment Design
MH  - Mechanical Thrombolysis/*instrumentation/methods
MH  - Models, Animal
MH  - Models, Cardiovascular
MH  - Polymers
MH  - Renal Artery/injuries
MH  - Renal Artery Obstruction/therapy
MH  - Thrombolytic Therapy
MH  - Tissue Plasminogen Activator/therapeutic use
MH  - Vibration
EDAT- 2012/07/24 06:00
MHDA- 2013/01/26 06:00
CRDT- 2012/07/24 06:00
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2013/01/26 06:00 [medline]
AID - 10.1097/MAT.0b013e31825f341c [doi]
PST - ppublish
SO  - ASAIO J. 2012 Sep-Oct;58(5):503-8. doi: 10.1097/MAT.0b013e31825f341c.