PMID- 22821288
OWN - NLM
STAT- MEDLINE
DCOM- 20130502
LR  - 20201226
IS  - 1439-3824 (Electronic)
IS  - 0300-8630 (Linking)
VI  - 224
IP  - 6
DP  - 2012 Oct
TI  - Human leukocyte antigen distribution in German Caucasians with advanced Ewing's 
      sarcoma.
PG  - 353-8
LID - 10.1055/s-0032-1321730 [doi]
AB  - BACKGROUND: Risk stratification criteria for patients with Ewing's sarcoma family 
      of tumors (ESFT) are still limited. We hypothesized divergent human leukocyte 
      antigen (HLA) patterns in ESFT patients and compared HLA-A, -B and -DR phenotype 
      frequencies of patients with advanced ESFT with those of healthy controls. 
      PATIENTS: HLA types of all German Caucasian patients with advanced ESFT and 
      available HLA-A, -B and -DR data registered in the European Group for Blood and 
      Marrow Transplantation, Paediatric Registry for Stem Cell Transplantation and the 
      MetaEICESS data bases (study group, n=30) were retrospectively compared with HLA 
      types of healthy German stem cell donors (control group, n=8 862 for single HLA 
      frequencies and n=8 839 for allele combinations). Study group patients had been 
      immuno-typed due to eligibility for allogeneic stem cell transplantation for high 
      risk of treatment failure, and thus constituted a selected subgroup of ESFT 
      patients. RESULTS: After Bonferroni correction for multiple testing (PC), 
      phenotype frequencies of HLA-A24 remained significantly higher in the study group 
      compared to controls (PC<0.05). Furthermore, several HLA combinations were 
      significantly more frequent in the study group compared to controls (all 
      PC<0.05). CONCLUSION: We report an increased incidence of circumscribed HLA 
      patterns in German Caucasians with advanced ESFT. The possible clinical 
      significance of this observation has to be re-assessed in prospective trials 
      comprising larger ESFT patient numbers of all risk groups.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Thiel, U
AU  - Thiel U
AD  - Department of Pediatrics and Pediatric Oncology Center, Klinikum rechts der Isar 
      der Technischen Universitat Munchen, Munich, Germany. uwe.thiel@lrz.tum.de
FAU - Wolf, P
AU  - Wolf P
FAU - Wawer, A
AU  - Wawer A
FAU - Blaeschke, F
AU  - Blaeschke F
FAU - Grunewald, T G P
AU  - Grunewald TG
FAU - von Luttichau, I T
AU  - von Luttichau IT
FAU - Klingebiel, T
AU  - Klingebiel T
FAU - Bader, P
AU  - Bader P
FAU - Borkhardt, A
AU  - Borkhardt A
FAU - Laws, H-J
AU  - Laws HJ
FAU - Handgretinger, R
AU  - Handgretinger R
FAU - Lang, P
AU  - Lang P
FAU - Schlegel, P G
AU  - Schlegel PG
FAU - Eyrich, M
AU  - Eyrich M
FAU - Gruhn, B
AU  - Gruhn B
FAU - Ehninger, G
AU  - Ehninger G
FAU - Koscielniak, E
AU  - Koscielniak E
FAU - Klein, C
AU  - Klein C
FAU - Sykora, K-W
AU  - Sykora KW
FAU - Holler, E
AU  - Holler E
FAU - Mauz-Korholz, C
AU  - Mauz-Korholz C
FAU - Woessmann, W
AU  - Woessmann W
FAU - Richter, G H S
AU  - Richter GH
FAU - Schmidt, A H
AU  - Schmidt AH
FAU - Peters, C
AU  - Peters C
FAU - Dirksen, U
AU  - Dirksen U
FAU - Jurgens, H
AU  - Jurgens H
FAU - Bregni, M
AU  - Bregni M
FAU - Burdach, S
AU  - Burdach S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120720
PL  - Germany
TA  - Klin Padiatr
JT  - Klinische Padiatrie
JID - 0326144
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Blood Donors
MH  - *Bone Marrow Transplantation
MH  - Bone Neoplasms/*genetics/pathology/*therapy
MH  - Child
MH  - Disease Progression
MH  - Female
MH  - Gene Frequency
MH  - Genetics, Population
MH  - Germany
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Male
MH  - Neoplasm Recurrence, Local/genetics/pathology/therapy
MH  - Neoplasm Staging
MH  - Retrospective Studies
MH  - Sarcoma, Ewing/*genetics/pathology/*therapy
MH  - *Tissue Donors
MH  - Young Adult
EDAT- 2012/07/24 06:00
MHDA- 2013/05/03 06:00
CRDT- 2012/07/24 06:00
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2013/05/03 06:00 [medline]
AID - 10.1055/s-0032-1321730 [doi]
PST - ppublish
SO  - Klin Padiatr. 2012 Oct;224(6):353-8. doi: 10.1055/s-0032-1321730. Epub 2012 Jul 
      20.