PMID- 22821806
OWN - NLM
STAT- MEDLINE
DCOM- 20140204
LR  - 20161125
IS  - 1545-1097 (Print)
IS  - 1545-1097 (Linking)
VI  - 11
IP  - 5
DP  - 2012 Sep-Oct
TI  - Immune Reconstitution Inflammatory Syndrome (IRIS) with acute tuberculous 
      osteomyelitis and disseminated mutilating tuberculous dactylitis in a person 
      living with HIV and AIDS (PLHA): a case report.
PG  - 289-92
AB  - HIV infection changed the scenario of infectious diseases. The pre-HAART (highly 
      active antiretroviral therapy) era had resulted in new opportunistic infections. 
      HIV and tuberculosis together had high mortality in countries with high 
      prevalence of tuberculosis. Disseminated and extra pulmonary tuberculosis is 
      common in PLHA (People Living with HIV and AIDS). IRIS (Immune Reconstitution 
      Inflammatory Syndrome) after HAART is common (10% to 25%) in PLHA. Pott's spine 
      is the most common presentation in PLHA of bone and skeletal system. IRIS 
      tuberculosis, especially extra pulmonary tuberculosis, is the most common. In 
      this case, we are presenting an IRIS disseminated tuberculosis in the form of 
      acute osteomyelitis and mutilating dactylitis involving many joints of the 
      fingers. Of 37 cases (9 from India) reported worldwide multiple dactylitis was 
      never presented in the medical journals. This might be the first multiple 
      dactylitis with extensive mutilation to the dactyls due to IRIS in a patient on 
      ART.
FAU - Krishnaraj, Raja
AU  - Krishnaraj R
AD  - 1Center of Excellence for HIV and TB, Government Hospital of Thoracic Medicine, 
      Tambaram, Chennai, Tamil Nadu, India.
FAU - Chockalingam, Chandrasekar
AU  - Chockalingam C
FAU - Krishnarajasekhar, O R
AU  - Krishnarajasekhar OR
FAU - Ayyamperumal, Mahilmaran
AU  - Ayyamperumal M
FAU - Narayanan, Ravichandran
AU  - Narayanan R
FAU - Satagopan, Kumar
AU  - Satagopan K
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120720
PL  - United States
TA  - J Int Assoc Physicians AIDS Care (Chic)
JT  - Journal of the International Association of Physicians in AIDS Care (Chicago, 
      Ill. : 2002)
JID - 101185740
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-HIV Agents)
RN  - 75J73V1629 (Ceftriaxone)
RN  - O6X5QGC2VB (Cloxacillin)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/drug therapy/*microbiology
MH  - Adult
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Anti-HIV Agents/adverse effects
MH  - Ceftriaxone/therapeutic use
MH  - Cloxacillin/therapeutic use
MH  - *Finger Joint
MH  - HIV Infections/drug therapy
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*complications
MH  - *Klebsiella pneumoniae
MH  - Male
MH  - Osteomyelitis/complications/drug therapy/*microbiology
MH  - Radiography
MH  - *Toe Joint
MH  - Tuberculosis, Osteoarticular/*complications/diagnostic imaging
EDAT- 2012/07/24 06:00
MHDA- 2014/02/05 06:00
CRDT- 2012/07/24 06:00
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2014/02/05 06:00 [medline]
AID - 1545109712449866 [pii]
AID - 10.1177/1545109712449866 [doi]
PST - ppublish
SO  - J Int Assoc Physicians AIDS Care (Chic). 2012 Sep-Oct;11(5):289-92. doi: 
      10.1177/1545109712449866. Epub 2012 Jul 20.