PMID- 22822460
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20240321
IS  - 2093-3673 (Electronic)
IS  - 2093-3665 (Print)
IS  - 2093-3665 (Linking)
VI  - 45
IP  - 2
DP  - 2012 Jun
TI  - From tumor hypoxia to cancer progression: the implications of hypoxia-inducible 
      factor-1 expression in cancers.
PG  - 73-8
LID - 10.5115/acb.2012.45.2.73 [doi]
AB  - Hypoxia, defined as a decrease of tissue oxygen levels, represents a fundamental 
      pathophysiological condition in the microenvironment of solid tumors. Tumor 
      hypoxia is known to be associated with radio/chemo-resistance and metastasis that 
      eventually lead to cancer progression contributing to poor prognosis in cancer 
      patients. Among transcription factors that accumulated under hypoxic conditions, 
      hypoxia-inducible factor-1 (HIF-1) is a master transcription factor that has 
      received the most intense attention in this field of research due to its capacity 
      to modulate several hundred genes. With a clearer understanding of the HIF-1 
      pathway, efforts are directed at manipulation of this complex genetic process in 
      order to ultimately decrease cellular HIF-1 levels. Some novel agents have been 
      shown to have HIF-1 inhibition activity through a variety of molecular mechanisms 
      and have provided promising results in the preclinical setting.
FAU - Nurwidya, Fariz
AU  - Nurwidya F
AD  - Department of Respiratory Medicine, Juntendo University School of Medicine, 
      Tokyo, Japan.
FAU - Takahashi, Fumiyuki
AU  - Takahashi F
FAU - Minakata, Kunihiko
AU  - Minakata K
FAU - Murakami, Akiko
AU  - Murakami A
FAU - Takahashi, Kazuhisa
AU  - Takahashi K
LA  - eng
PT  - Journal Article
DEP - 20120630
PL  - Korea (South)
TA  - Anat Cell Biol
JT  - Anatomy & cell biology
JID - 101531987
PMC - PMC3398177
OTO - NOTNLM
OT  - Cancer progression
OT  - Hypoxia-inducible factor-1
OT  - Tumor hypoxia
EDAT- 2012/07/24 06:00
MHDA- 2012/07/24 06:01
PMCR- 2012/06/01
CRDT- 2012/07/24 06:00
PHST- 2012/03/09 00:00 [received]
PHST- 2012/05/14 00:00 [accepted]
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2012/07/24 06:01 [medline]
PHST- 2012/06/01 00:00 [pmc-release]
AID - 10.5115/acb.2012.45.2.73 [doi]
PST - ppublish
SO  - Anat Cell Biol. 2012 Jun;45(2):73-8. doi: 10.5115/acb.2012.45.2.73. Epub 2012 Jun 
      30.