PMID- 22824011
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20240318
IS  - 1824-7288 (Electronic)
IS  - 1720-8424 (Linking)
VI  - 38
DP  - 2012 Jul 23
TI  - The immunopathogenesis of cow's milk protein allergy (CMPA).
PG  - 35
LID - 10.1186/1824-7288-38-35 [doi]
AB  - The most frequent symptoms among the manifestations of cow milk protein allergy 
      (CMPA) are gastrointestinal. CMPA pathogenesis involves immunological mechanisms 
      with participation of immunocompetent cells and production of immunoglobulin E 
      (IgE). Nevertheless, recent studies have been focused on the description of other 
      forms of CMPA, not-mediated by IgE reactions, mostly involving the T lymphocite 
      immune system. Thus, in this field it is important to note how different kind of 
      cells are involved in the immunopathogenesis of CMPA, such as antigen-specific T 
      cells, T regulatory cells, cytokines secreted by the different T lymphocite 
      subsets, B lymphocytes, antingen-presenting cells, mast cells, that together 
      orchestrate the complex mechanism leading to the phenotipic expression of 
      CMPA.The progress in the diagnosis of immunologic disorders allowed the recent 
      literature to develop new models for immuno-mediate disorders, involving new 
      cells (such as Treg cells) and thus allowing the acquisition of a new vision of 
      the pathogenesis of atopic diseases.The aim of this review is to describe the 
      immunopathogenetic aspects of CMPA in view of these new discoveries in the 
      immunologic field, considering the immunologic pathway at the basis of both IgE- 
      and not-IgE mediated CMPA.
FAU - Vitaliti, Giovanna
AU  - Vitaliti G
FAU - Cimino, Carla
AU  - Cimino C
FAU - Coco, Alfina
AU  - Coco A
FAU - Pratico, Andrea Domenico
AU  - Pratico AD
FAU - Lionetti, Elena
AU  - Lionetti E
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120723
PL  - England
TA  - Ital J Pediatr
JT  - Italian journal of pediatrics
JID - 101510759
RN  - 0 (Milk Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
EIN - Ital J Pediatr. 2014;39:82. Giovanna, Vitaliti [corrected to Vitaliti, Giovanna]; 
      Carla, Cimino [corrected to Cimino, Carla]; Alfina, Coco [corrected to Coco, 
      Alfina]; Deoenico, Pratico Andrea [corrected to Pratico, Andrea Domenico]; Elena, 
      Lionetti [corrected to Lionetti, Elena]
MH  - Animals
MH  - Cattle
MH  - Child
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Milk Hypersensitivity/*immunology
MH  - Milk Proteins/*immunology
MH  - Probiotics/pharmacology
MH  - T-Lymphocytes, Regulatory/immunology
PMC - PMC3441837
EDAT- 2012/07/25 06:00
MHDA- 2013/01/05 06:00
PMCR- 2012/07/23
CRDT- 2012/07/25 06:00
PHST- 2012/06/05 00:00 [received]
PHST- 2012/07/09 00:00 [accepted]
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
PHST- 2012/07/23 00:00 [pmc-release]
AID - 1824-7288-38-35 [pii]
AID - 10.1186/1824-7288-38-35 [doi]
PST - epublish
SO  - Ital J Pediatr. 2012 Jul 23;38:35. doi: 10.1186/1824-7288-38-35.