PMID- 22825696
OWN - NLM
STAT- MEDLINE
DCOM- 20130115
LR  - 20121105
IS  - 1432-8798 (Electronic)
IS  - 0304-8608 (Linking)
VI  - 157
IP  - 11
DP  - 2012 Nov
TI  - Tracing the genetic history of porcine reproductive and respiratory syndrome 
      viruses derived from the complete ORF 5-7 sequences: a Bayesian coalescent 
      approach.
PG  - 2143-51
LID - 10.1007/s00705-012-1408-6 [doi]
AB  - To trace the genetic history of porcine reproductive and respiratory syndrome 
      virus (PRRSV), we determined the complete sequences of ORFs 5 to 7 of four PRRSV 
      isolates. These sequences were analyzed together with published sequences from 
      146 isolates from various parts of the world using a Bayesian coalescent approach 
      as well as Bayesian inference and maximum-likelihood methods. All of the 
      European-type (EU-type) viruses were classified into one of two groups or 
      unclassified (4 isolates), while all North American-type (NA-type) viruses 
      belonged to one of three major groups or were unclassified (5 isolates). Within 
      each genotype, no apparent periodic and/or geographic influence on the evolution 
      of PRRSVs was observed. The evolutionary rate of PRRSV isolates was estimated to 
      be 1.55 x 10(-3) substitutions/site/year, and the time of the most recent common 
      ancestor (TMRCA) was 491.2 years ago. Here, the TMRCA for the EU- and NA-type 
      viruses was 58.7 and 62.6 years ago, respectively. A Bayesian skyline plot 
      revealed that the viruses evolved at an almost constant population size until the 
      late 1970s, when they experienced a population expansion that continued until the 
      late 1980s. The population size then remained constant again until the early 
      2000s, when a rapid, sharp decline in the effective number of infections 
      occurred.
FAU - Yoon, Sook Hee
AU  - Yoon SH
AD  - Department of Agricultural Biotechnology and Research Institute for Agriculture 
      and Life Sciences, Seoul National University, Seoul 151-742, Republic of Korea.
FAU - Kim, Hyekwon
AU  - Kim H
FAU - Park, Bongkyun
AU  - Park B
FAU - Kim, Heebal
AU  - Kim H
LA  - eng
SI  - GENBANK/JN809804
SI  - GENBANK/JN809805
SI  - GENBANK/JN809806
SI  - GENBANK/JN809807
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120724
PL  - Austria
TA  - Arch Virol
JT  - Archives of virology
JID - 7506870
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Animals
MH  - Cluster Analysis
MH  - *Evolution, Molecular
MH  - Genotype
MH  - Molecular Sequence Data
MH  - Mutation Rate
MH  - *Open Reading Frames
MH  - *Phylogeography
MH  - Porcine Reproductive and Respiratory Syndrome/virology
MH  - Porcine respiratory and reproductive syndrome 
      virus/*classification/*genetics/isolation & purification
MH  - RNA, Viral/genetics
MH  - Sequence Analysis, DNA
MH  - Swine
EDAT- 2012/07/25 06:00
MHDA- 2013/01/16 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/03/30 00:00 [received]
PHST- 2012/05/26 00:00 [accepted]
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2013/01/16 06:00 [medline]
AID - 10.1007/s00705-012-1408-6 [doi]
PST - ppublish
SO  - Arch Virol. 2012 Nov;157(11):2143-51. doi: 10.1007/s00705-012-1408-6. Epub 2012 
      Jul 24.