PMID- 22826377
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20221207
IS  - 1940-1574 (Electronic)
IS  - 0003-3197 (Linking)
VI  - 64
IP  - 6
DP  - 2013 Aug
TI  - The epsilon4 allele of the APOE gene is associated with more severe peripheral 
      neuropathy in type 2 diabetic patients.
PG  - 451-5
LID - 10.1177/0003319712453645 [doi]
AB  - We examined the association between the epsilon4 allele of the apolipoprotein E gene 
      and severity of peripheral neuropathy in 234 patients with type 2 diabetes 
      mellitus (T2DM). Based on the Neuropathy Disability Score (NDS), patients were 
      divided into group A (NDS </= 6: mild or no neuropathy) and group B (NDS > 6: 
      severe neuropathy). In each group, patients were further divided into epsilon4 carriers 
      and non-epsilon4 carriers. In multivariate analysis, a more than 5-fold increased risk 
      of severe neuropathy was associated with epsilon4 carrier status (adjusted odds ratio 
      [aOR]: 5.26, 95% confidence interval [CI]: 2.24-12.31, P = .0001). The other 
      significant risk factors for severe neuropathy included male gender (aOR: 2.08, 
      95% CI: 1.05-4.14, P = .036), diabetes duration (aOR: 1.05, 95% CI: 1.00-1.09, P 
      = .039), and hemoglobin A1c (aOR: 1.32, 95% CI: 1.05-1.66, P = .020). In 
      conclusion, the epsilon4 carrier status appears to be associated with severe peripheral 
      neuropathy in T2DM.
FAU - Monastiriotis, C
AU  - Monastiriotis C
AD  - Outpatient Clinic of the Diabetic Foot, Second Department of Internal Medicine, 
      Democritus University of Thrace, Greece. c_monastiriotis@yahoo.com
FAU - Papanas, N
AU  - Papanas N
FAU - Trypsianis, G
AU  - Trypsianis G
FAU - Karanikola, K
AU  - Karanikola K
FAU - Veletza, S
AU  - Veletza S
FAU - Maltezos, E
AU  - Maltezos E
LA  - eng
PT  - Journal Article
DEP - 20120723
PL  - United States
TA  - Angiology
JT  - Angiology
JID - 0203706
RN  - 0 (Apolipoproteins E)
RN  - 0 (Biomarkers)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Apolipoproteins E/*genetics
MH  - Biomarkers/blood
MH  - Chi-Square Distribution
MH  - Diabetes Mellitus, Type 2/complications/diagnosis/*genetics
MH  - Diabetic Neuropathies/diagnosis/*genetics
MH  - Disability Evaluation
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Phenotype
MH  - Predictive Value of Tests
MH  - Risk Assessment
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Sex Factors
OTO - NOTNLM
OT  - apolipoprotein E
OT  - diabetes mellitus
OT  - diabetic neuropathy
OT  - genes
OT  - polymorphisms
EDAT- 2012/07/25 06:00
MHDA- 2013/10/18 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - 0003319712453645 [pii]
AID - 10.1177/0003319712453645 [doi]
PST - ppublish
SO  - Angiology. 2013 Aug;64(6):451-5. doi: 10.1177/0003319712453645. Epub 2012 Jul 23.