PMID- 22826551
OWN - NLM
STAT- MEDLINE
DCOM- 20121120
LR  - 20220409
IS  - 1468-2079 (Electronic)
IS  - 0007-1161 (Print)
IS  - 0007-1161 (Linking)
VI  - 96
IP  - 9
DP  - 2012 Sep
TI  - Fundus autofluorescence and spectral-domain optical coherence tomography findings 
      suggesting tissue remodelling in retinal pigment epithelium tear.
PG  - 1211-6
LID - 10.1136/bjophthalmol-2012-301750 [doi]
AB  - AIM: To study tissue remodelling and wound healing after retinal pigment 
      epithelium (RPE) tears due to age-related macular degeneration. METHODS: 
      Retrospective longitudinal study of 36 eyes (33 patients) with RPE tears. Imaging 
      was performed using fundus autofluorescence (FAF) (lambda=488 nm) and spectral-domain 
      optical coherence tomography (SD-OCT). Presence of intraretinal hyper-reflective 
      dots in SD-OCT, which correlated with hyperfluorescent dots in FAF, indicating 
      RPE migration was studied. Morphology of subretinal mass and RPE layer integrity 
      in the RPE denuded area over time were examined. RESULTS: 7 of 36 eyes (19.4%) 
      showed patchy or hazy hyperfluorescent areas in FAF, and the majority of eyes 
      (83.3%) showed hyper-reflective dots, which possibly represent intraretinal RPE 
      migration and hard exudates. Homogenous subretinal mass was encountered in about 
      half of all cases. In one case (2.8%), the RPE layer proliferated and covered the 
      defect. CONCLUSIONS: SD-OCT and FAF showed a considerable amount of RPE 
      proliferation, migration and repopulation. Intraretinal RPE migration did not 
      form a functional RPE layer. A small defect might be repaired by cell 
      proliferation. But this RPE proliferation is not sufficient to cover large 
      defects.
FAU - Caramoy, Albert
AU  - Caramoy A
AD  - Department of Vitreoretinal Surgery, Center of Ophthalmology, University of 
      Cologne, Kerpenerstr. 62, 50924 Cologne, Germany. acaramoy@yahoo.co.uk
FAU - Fauser, Sascha
AU  - Fauser S
FAU - Kirchhof, Bernd
AU  - Kirchhof B
LA  - eng
PT  - Journal Article
DEP - 20120723
PL  - England
TA  - Br J Ophthalmol
JT  - The British journal of ophthalmology
JID - 0421041
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cell Division/physiology
MH  - Female
MH  - *Fluorescein Angiography
MH  - Humans
MH  - Longitudinal Studies
MH  - Macular Degeneration/complications
MH  - Male
MH  - Middle Aged
MH  - Retinal Detachment/etiology/*pathology/*physiopathology
MH  - Retinal Pigment Epithelium/pathology/physiology
MH  - Retrospective Studies
MH  - *Tomography, Optical Coherence
MH  - Wound Healing/*physiology
PMC - PMC3432490
COIS- Competing interests: None.
EDAT- 2012/07/25 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - bjophthalmol-2012-301750 [pii]
AID - 10.1136/bjophthalmol-2012-301750 [doi]
PST - ppublish
SO  - Br J Ophthalmol. 2012 Sep;96(9):1211-6. doi: 10.1136/bjophthalmol-2012-301750. 
      Epub 2012 Jul 23.