PMID- 22829628
OWN - NLM
STAT- MEDLINE
DCOM- 20121218
LR  - 20211021
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 120
IP  - 14
DP  - 2012 Oct 4
TI  - Evaluation of HLA matching in unrelated hematopoietic stem cell transplantation 
      for nonmalignant disorders.
PG  - 2918-24
LID - 10.1182/blood-2012-03-417758 [doi]
AB  - The importance of human leukocyte antigen (HLA) matching in unrelated donor 
      transplantation for nonmalignant diseases (NMD) has yet to be defined. We 
      analyzed data from 663 unrelated marrow and peripheral blood stem cell 
      transplants performed from 1995 to 2007 for treatment of NMD. Transplantation 
      from a donor mismatched at the HLA-A, -B, -C, or -DRB1, but not -DQB1 or -DPB1, 
      loci was associated with higher mortality in multivariate analyses (P = .002). 
      The hazard ratio for mortality for single (7/8) and double mismatched (6/8) 
      transplants was 1.29 (0.97-1.72; P = .079) and 1.82 (1.30-2.55; P = .0004), 
      respectively, compared with 8/8 matched transplants. HLA mismatches were not 
      associated with acute or chronic GVHD, but were strongly associated with graft 
      failure. After adjustment for other factors, the odds ratio for graft failure for 
      7/8 and 6/8 (allele and/or antigen) matched pairs compared with 8/8 matched 
      transplants was 2.81 (1.74-4.54; P < .0001) and 2.22 (1.26-3.97; P = .006), 
      respectively. Patients with NMD should receive transplants from allele matched 
      (8/8) donors if possible. Unlike the case with malignancies, HLA mismatching in 
      NMD is associated with graft failure rather than GVHD.
FAU - Horan, John
AU  - Horan J
AD  - Emory University, Atlanta, GA 30322, USA. john.horan@choa.org
FAU - Wang, Tao
AU  - Wang T
FAU - Haagenson, Michael
AU  - Haagenson M
FAU - Spellman, Stephen R
AU  - Spellman SR
FAU - Dehn, Jason
AU  - Dehn J
FAU - Eapen, Mary
AU  - Eapen M
FAU - Frangoul, Haydar
AU  - Frangoul H
FAU - Gupta, Vikas
AU  - Gupta V
FAU - Hale, Gregory A
AU  - Hale GA
FAU - Hurley, Carolyn K
AU  - Hurley CK
FAU - Marino, Susana
AU  - Marino S
FAU - Oudshoorn, Machteld
AU  - Oudshoorn M
FAU - Reddy, Vijay
AU  - Reddy V
FAU - Shaw, Peter
AU  - Shaw P
FAU - Lee, Stephanie J
AU  - Lee SJ
FAU - Woolfrey, Ann
AU  - Woolfrey A
LA  - eng
GR  - 5U01HL069294/HL/NHLBI NIH HHS/United States
GR  - U24 CA076518/CA/NCI NIH HHS/United States
GR  - HHSH234200637015C/PHS HHS/United States
GR  - U24-CA76518/CA/NCI NIH HHS/United States
GR  - U01 HL069294/HL/NHLBI NIH HHS/United States
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20120724
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (HLA Antigens)
SB  - IM
CIN - Blood. 2012 Oct 4;120(14):2781-2. PMID: 23043027
MH  - Adolescent
MH  - Adult
MH  - Blood Donors
MH  - Bone Marrow Transplantation
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Graft Rejection/*immunology
MH  - Graft vs Host Disease/*etiology/*mortality
MH  - HLA Antigens/*immunology
MH  - Hematologic Diseases/*complications/therapy
MH  - Histocompatibility/*immunology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Middle Aged
MH  - Peripheral Blood Stem Cell Transplantation
MH  - Survival Rate
MH  - Unrelated Donors
MH  - Young Adult
PMC - PMC3466972
EDAT- 2012/07/26 06:00
MHDA- 2012/12/19 06:00
PMCR- 2013/10/04
CRDT- 2012/07/26 06:00
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2012/12/19 06:00 [medline]
PHST- 2013/10/04 00:00 [pmc-release]
AID - S0006-4971(20)46348-7 [pii]
AID - 2012/417758 [pii]
AID - 10.1182/blood-2012-03-417758 [doi]
PST - ppublish
SO  - Blood. 2012 Oct 4;120(14):2918-24. doi: 10.1182/blood-2012-03-417758. Epub 2012 
      Jul 24.