PMID- 22829817
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1687-8205 (Electronic)
IS  - 1687-8191 (Print)
IS  - 1687-8191 (Linking)
VI  - 2012
DP  - 2012
TI  - Mining the virgin land of neurotoxicology: a novel paradigm of neurotoxic 
      peptides action on glycosylated voltage-gated sodium channels.
PG  - 843787
LID - 10.1155/2012/843787 [doi]
LID - 843787
AB  - Voltage-gated sodium channels (VGSCs) are important membrane protein carrying on 
      the molecular basis for action potentials (AP) in neuronal firings. Even though 
      the structure-function studies were the most pursued spots, the posttranslation 
      modification processes, such as glycosylation, phosphorylation, and alternative 
      splicing associating with channel functions captured less eyesights. The 
      accumulative research suggested an interaction between the sialic acids chains 
      and ion-permeable pores, giving rise to subtle but significant impacts on channel 
      gating. Sodium channel-specific neurotoxic toxins, a family of long-chain 
      polypeptides originated from venomous animals, are found to potentially share the 
      binding sites adjacent to glycosylated region on VGSCs. Thus, an interaction 
      between toxin and glycosylated VGSC might hopefully join the campaign to approach 
      the role of glycosylation in modulating VGSCs-involved neuronal network activity. 
      This paper will cover the state-of-the-art advances of researches on 
      glycosylation-mediated VGSCs function and the possible underlying mechanisms of 
      interactions between toxin and glycosylated VGSCs, which may therefore, fulfill 
      the knowledge in identifying the pharmacological targets and therapeutic values 
      of VGSCs.
FAU - Liu, Zhirui
AU  - Liu Z
AD  - Laboratory of Neuropharmacology and Neurotoxicology, Shanghai University, Nanchen 
      Road 333, Shanghai 200444, China.
FAU - Tao, Jie
AU  - Tao J
FAU - Ye, Pin
AU  - Ye P
FAU - Ji, Yonghua
AU  - Ji Y
LA  - eng
PT  - Journal Article
DEP - 20120708
PL  - Egypt
TA  - J Toxicol
JT  - Journal of toxicology
JID - 101519097
PMC - PMC3399347
EDAT- 2012/07/26 06:00
MHDA- 2012/07/26 06:01
PMCR- 2012/07/08
CRDT- 2012/07/26 06:00
PHST- 2012/02/15 00:00 [received]
PHST- 2012/04/17 00:00 [revised]
PHST- 2012/05/24 00:00 [accepted]
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2012/07/26 06:01 [medline]
PHST- 2012/07/08 00:00 [pmc-release]
AID - 10.1155/2012/843787 [doi]
PST - ppublish
SO  - J Toxicol. 2012;2012:843787. doi: 10.1155/2012/843787. Epub 2012 Jul 8.