PMID- 22829833
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1687-8884 (Electronic)
IS  - 1687-8876 (Print)
IS  - 1687-8876 (Linking)
VI  - 2012
DP  - 2012
TI  - Caloric Restriction and the Nutrient-Sensing PGC-1alpha in Mitochondrial Homeostasis: 
      New Perspectives in Neurodegeneration.
PG  - 759583
LID - 10.1155/2012/759583 [doi]
LID - 759583
AB  - Mitochondrial activity progressively declines during ageing and in many 
      neurodegenerative diseases. Caloric restriction (CR) has been suggested as a 
      dietary intervention that is able to postpone the detrimental aspects of aging as 
      it ameliorates mitochondrial performance. This effect is partially due to 
      increased mitochondrial biogenesis. The nutrient-sensing PGC-1alpha is a 
      transcriptional coactivator that promotes the expression of mitochondrial genes 
      and is induced by CR. It is believed that many of the mitochondrial and metabolic 
      benefits of CR are due to increased PGC-1alpha activity. The increase of PGC-1alpha is 
      also positively linked to neuroprotection and its decrement has been involved in 
      the pathogenesis of many neurodegenerative diseases. This paper aims to summarize 
      the current knowledge about the role of PGC-1alpha in neuronal homeostasis and the 
      beneficial effects of CR on mitochondrial biogenesis and function. We also 
      discuss how PGC-1alpha-governed pathways could be used as target for nutritional 
      intervention to prevent neurodegeneration.
FAU - Lettieri Barbato, Daniele
AU  - Lettieri Barbato D
AD  - Department of Biology, University of Rome "Tor Vergata", Via della Ricerca 
      Scientifica 1, 00133 Rome, Italy.
FAU - Baldelli, Sara
AU  - Baldelli S
FAU - Pagliei, Beatrice
AU  - Pagliei B
FAU - Aquilano, Katia
AU  - Aquilano K
FAU - Ciriolo, Maria Rosa
AU  - Ciriolo MR
LA  - eng
PT  - Journal Article
DEP - 20120708
PL  - United States
TA  - Int J Cell Biol
JT  - International journal of cell biology
JID - 101517861
PMC - PMC3399559
EDAT- 2012/07/26 06:00
MHDA- 2012/07/26 06:01
PMCR- 2012/07/08
CRDT- 2012/07/26 06:00
PHST- 2012/05/07 00:00 [received]
PHST- 2012/06/08 00:00 [accepted]
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2012/07/26 06:01 [medline]
PHST- 2012/07/08 00:00 [pmc-release]
AID - 10.1155/2012/759583 [doi]
PST - ppublish
SO  - Int J Cell Biol. 2012;2012:759583. doi: 10.1155/2012/759583. Epub 2012 Jul 8.