PMID- 22829961
OWN - NLM
STAT- MEDLINE
DCOM- 20121106
LR  - 20230429
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2012
DP  - 2012
TI  - Schizandrin, an antioxidant lignan from Schisandra chinensis, ameliorates 
      Abeta1-42-induced memory impairment in mice.
PG  - 721721
LID - 10.1155/2012/721721 [doi]
LID - 721721
AB  - In the present study, we examined the effect of schisandrin (SCH) of Schisandra 
      chinensis on the amyloid-beta(1-42)- (Abeta(1-42)-) induced memory impairment in 
      mice and elucidated the possible antioxidative mechanism. Mice were 
      intracerebroventricular (i.c.v.) injected with the aggregated Abeta(1-42) and then 
      treated with SCH (4, 12, and 36 mg/kg body weight) or donepezil (DPZ), a 
      reference drug (0.65 mg/kg) by intragastric infusion for 14 days. Noncognitive 
      disturbances and cognitive performance were evaluated by locomotor activity test, 
      Y-maze test, and water maze test. Antioxidative enzyme activities including 
      superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) and levels of 
      malondialdehyde (MDA), glutathione (GSH), and oxidized glutathione (GSSG) within 
      the cerebral cortex and hippocampus of mice were measured to elucidate the 
      mechanism. Our results showed that SCH significantly improved Abeta(1-42)-induced 
      short-term and spatial reference memory impairments in Y-maze test and water maze 
      test. Furthermore, in the cerebral cortex and hippocampus of mice, SOD and GSH-px 
      activities, GSH level, and GSH/GSSG ratio were increased, and levels of MDA and 
      GSSG were decreased by the treatment of SCH. These results suggest that SCH is a 
      potential cognitive enhancer against Alzheimer's disease through antioxidative 
      action.
FAU - Hu, Di
AU  - Hu D
AD  - Department of Pharmacognosy, Shenyang Pharmaceutical University, China.
FAU - Cao, Yunfeng
AU  - Cao Y
FAU - He, Rongrong
AU  - He R
FAU - Han, Na
AU  - Han N
FAU - Liu, Zhihui
AU  - Liu Z
FAU - Miao, Lijing
AU  - Miao L
FAU - Yin, Jun
AU  - Yin J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120704
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Antioxidants)
RN  - 0 (Cyclooctanes)
RN  - 0 (Lignans)
RN  - 0 (Peptide Fragments)
RN  - 0 (Polycyclic Compounds)
RN  - 0 (amyloid beta-protein (1-42))
RN  - G01BQC0879 (schizandrin)
SB  - IM
MH  - Amyloid beta-Peptides/*toxicity
MH  - Animals
MH  - Antioxidants/chemistry/metabolism/pharmacology/*therapeutic use
MH  - Biological Assay
MH  - Cerebral Cortex/drug effects/enzymology/pathology/physiopathology
MH  - Cyclooctanes/chemistry/pharmacology/*therapeutic use
MH  - Hippocampus/drug effects/enzymology/pathology/physiopathology
MH  - Lignans/chemistry/pharmacology/*therapeutic use
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory Disorders/*drug therapy/physiopathology
MH  - Mice
MH  - Motor Activity/drug effects
MH  - Peptide Fragments/*toxicity
MH  - Polycyclic Compounds/chemistry/pharmacology/*therapeutic use
MH  - Reaction Time/drug effects
MH  - Schisandra/*chemistry
PMC - PMC3399599
EDAT- 2012/07/26 06:00
MHDA- 2012/11/07 06:00
PMCR- 2012/07/04
CRDT- 2012/07/26 06:00
PHST- 2012/03/07 00:00 [received]
PHST- 2012/05/14 00:00 [revised]
PHST- 2012/05/14 00:00 [accepted]
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2012/11/07 06:00 [medline]
PHST- 2012/07/04 00:00 [pmc-release]
AID - 10.1155/2012/721721 [doi]
PST - ppublish
SO  - Oxid Med Cell Longev. 2012;2012:721721. doi: 10.1155/2012/721721. Epub 2012 Jul 
      4.