PMID- 22830353
OWN - NLM
STAT- MEDLINE
DCOM- 20131217
LR  - 20171116
IS  - 1551-3823 (Electronic)
IS  - 1551-3815 (Linking)
VI  - 32
IP  - 3
DP  - 2013 Jun
TI  - Expression of stem cell markers, CD133 and CD44, in pediatric solid tumors: a 
      study using tissue microarray.
PG  - 192-204
LID - 10.3109/15513815.2012.701266 [doi]
AB  - Based on the cancer stem cell (CSC) concept model, a small population of cells 
      with unique self-renewal properties and malignant potential exists in tumors. 
      Immunohistochemistry was performed to detect the expression of CSC markers, CD133 
      and CD44, in a series of pediatric tumors. The association between expression of 
      these markers and tumor characteristics was then analyzed. In Wilms tumors (WT), 
      a significant positive correlation was found between expression of CD133 and the 
      National Wilms Tumor Stage (NWTS) (p = 0.047). In neuroblastomas (NB), expression 
      of CD133 was positively correlated with the International Neuroblastoma Staging 
      System (INSS) (p-value = 0.012), indicating that the rate of CD133 positivity 
      increased with the stage of these tumors. CD133, as a putative stem cell marker, 
      is associated with more advanced stages of Wilms and NB tumors; therefore, this 
      molecule can be a potential clinical prognostic marker in children suffering from 
      NB or Wilms tumor.
FAU - Mehrazma, Mitra
AU  - Mehrazma M
AD  - Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Madjd, Zahra
AU  - Madjd Z
FAU - Kalantari, Elham
AU  - Kalantari E
FAU - Panahi, Mahshid
AU  - Panahi M
FAU - Hendi, Alireza
AU  - Hendi A
FAU - Shariftabrizi, Ahmad
AU  - Shariftabrizi A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120725
PL  - England
TA  - Fetal Pediatr Pathol
JT  - Fetal and pediatric pathology
JID - 101230972
RN  - 0 (AC133 Antigen)
RN  - 0 (Antigens, CD)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CD44 protein, human)
RN  - 0 (Glycoproteins)
RN  - 0 (Hyaluronan Receptors)
RN  - 0 (PROM1 protein, human)
RN  - 0 (Peptides)
SB  - IM
MH  - AC133 Antigen
MH  - Antigens, CD/*metabolism
MH  - Biomarkers, Tumor/metabolism
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Glycoproteins/*metabolism
MH  - Hodgkin Disease/*metabolism/pathology/surgery
MH  - Humans
MH  - Hyaluronan Receptors/*metabolism
MH  - Infant
MH  - Kidney Neoplasms/*metabolism/pathology/surgery
MH  - Male
MH  - Neoplasm Staging
MH  - Neuroblastoma/*metabolism/pathology/surgery
MH  - Peptides/*metabolism
MH  - Prognosis
MH  - Retrospective Studies
MH  - Stem Cells/metabolism/pathology
MH  - Tissue Array Analysis
MH  - Wilms Tumor/*metabolism/pathology/surgery
EDAT- 2012/07/27 06:00
MHDA- 2013/12/18 06:00
CRDT- 2012/07/27 06:00
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - 10.3109/15513815.2012.701266 [doi]
PST - ppublish
SO  - Fetal Pediatr Pathol. 2013 Jun;32(3):192-204. doi: 10.3109/15513815.2012.701266. 
      Epub 2012 Jul 25.