PMID- 22832089
OWN - NLM
STAT- MEDLINE
DCOM- 20121226
LR  - 20231105
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Print)
IS  - 0048-9697 (Linking)
VI  - 433
DP  - 2012 Sep 1
TI  - Determinants of polychlorinated dibenzo-p-dioxins and polychlorinated 
      dibenzofurans in house dust samples from four areas of the United States.
PG  - 516-22
LID - 10.1016/j.scitotenv.2012.06.098 [doi]
AB  - Determinants of levels of polychlorinated dibenzo-p-dioxins and polychlorinated 
      dibenzofurans (PCDD/F) in dust in U.S. homes are not well characterized. We 
      conducted a pilot study to evaluate the relationship between concentrations of 
      PCDD/F in house dust and residential proximity to known sources, including 
      industrial facilities and traffic. Samples from vacuum bag dust from homes of 40 
      residents of Detroit, Los Angeles, Seattle, or Iowa who participated in a 
      population-based case-control study of non-Hodgkin lymphoma conducted in 
      1998-2000 were analyzed using high resolution gas chromatography/high resolution 
      mass spectrometry for 7 PCDD and 10 PCDF congeners considered toxic by the U.S. 
      Environmental Protection Agency (EPA). Locations of 10 types of PCDD/F-emitting 
      facilities were obtained from the EPA; however only 4 types were located near 
      study homes (non-hazardous waste cement kilns, coal-fired power plants, sewage 
      sludge incinerators, and medical waste incinerators). Relationships between 
      concentrations of each PCDD/F and proximity to industrial facilities, freight 
      routes, and major roads were evaluated using separate multivariate regression 
      models for each congener. The median (inter-quartile range [IQR]) toxic 
      equivalence (TEQ) concentration of these congeners in the house dust was 20.3 
      pg/g (IQR=14.3, 32.7). Homes within 3 or 5 km of a cement kiln had 2 to 9-fold 
      higher concentrations of 5 PCDD and 5 PCDF (p<0.1 in each model). Proximity to 
      freight routes and major roads was associated with elevated concentrations of 1 
      PCDD and 8 PCDF. Higher concentrations of certain PCDD/F in homes near cement 
      kilns, freight routes, and major roads suggest that these outdoor sources are 
      contributing to indoor environmental exposures. Further study of the contribution 
      of these sources and other facility types to total PCDD/F exposure in a larger 
      number of homes is warranted.
CI  - Published by Elsevier B.V.
FAU - Deziel, N C
AU  - Deziel NC
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 
      Department of Health and Human Services, Rockville, MD, United States. 
      dezielnc@mail.nih.gov
FAU - Nuckols, J R
AU  - Nuckols JR
FAU - Colt, J S
AU  - Colt JS
FAU - De Roos, A J
AU  - De Roos AJ
FAU - Pronk, A
AU  - Pronk A
FAU - Gourley, C
AU  - Gourley C
FAU - Severson, R K
AU  - Severson RK
FAU - Cozen, W
AU  - Cozen W
FAU - Cerhan, J R
AU  - Cerhan JR
FAU - Hartge, P
AU  - Hartge P
FAU - Ward, M H
AU  - Ward MH
LA  - eng
GR  - N01 PC067010/PC/NCI NIH HHS/United States
GR  - N01-CN-67008/CN/NCI NIH HHS/United States
GR  - N01 PC067008/PC/NCI NIH HHS/United States
GR  - N01-PC-67009/PC/NCI NIH HHS/United States
GR  - N01 PC065064/PC/NCI NIH HHS/United States
GR  - ImNIH/Intramural NIH HHS/United States
GR  - N01-CN-67010/CN/NCI NIH HHS/United States
GR  - N01 PC067009/CN/NCI NIH HHS/United States
GR  - N01 PC067009-025/CN/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120724
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Dust)
RN  - 0 (Polychlorinated Dibenzodioxins)
SB  - IM
MH  - Dust/*analysis
MH  - Polychlorinated Dibenzodioxins/*analysis
MH  - United States
PMC - PMC3431600
MID - NIHMS396689
EDAT- 2012/07/27 06:00
MHDA- 2012/12/27 06:00
PMCR- 2013/09/01
CRDT- 2012/07/27 06:00
PHST- 2012/04/18 00:00 [received]
PHST- 2012/06/25 00:00 [revised]
PHST- 2012/06/27 00:00 [accepted]
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2012/12/27 06:00 [medline]
PHST- 2013/09/01 00:00 [pmc-release]
AID - S0048-9697(12)00931-X [pii]
AID - 10.1016/j.scitotenv.2012.06.098 [doi]
PST - ppublish
SO  - Sci Total Environ. 2012 Sep 1;433:516-22. doi: 10.1016/j.scitotenv.2012.06.098. 
      Epub 2012 Jul 24.