PMID- 22832157
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20160519
IS  - 1663-2826 (Electronic)
IS  - 1663-2818 (Linking)
VI  - 78
IP  - 1
DP  - 2012
TI  - Elevated serum IL-6, IL-8, MCP-1, CRP, and IFN-gamma levels in 10- to 11-year-old 
      boys with increased BMI.
PG  - 31-9
LID - 10.1159/000339831 [doi]
AB  - BACKGROUND/AIMS: Many inflammation parameters are associated with obesity, but 
      few comparable data are found in youth. This study aims to characterize the 
      differences in serum levels of 13 biochemical inflammatory markers between boys 
      with increased BMI and boys with normal BMI, and examine the relationships 
      between inflammation markers, skinfold thicknesses, and body composition. 
      PARTICIPANTS/METHODS: The participants were 38 boys (BMI above 85th percentile) 
      and 38 boys (normal BMI) at the age of 10-11 years. Measurements included BMI, 9 
      skinfold thicknesses, waist and hip circumferences, and total body and trunk fat 
      mass and percentage as indices of obesity, fasting insulin, glucose, and serum 
      concentrations of IL-2, IL-4, IL-6, IL-8, IL-10, VEGF, IFN-gamma, TNF-alpha, IL-1alpha, 
      IL-1beta, monocyte chemoattractant protein-1 (MCP-1), epidermal growth factor, and 
      CRP. RESULTS: Overweight boys (OWB) were taller and more frequently in puberty 
      than normal-weight boys (NWB). Skinfold thicknesses and body composition 
      parameters were higher in OWB. They had significantly higher serum IL-6, IL-8, 
      IFN-gamma, MCP-1, and CRP values compared to NWB. CONCLUSIONS: Six of 13 measured 
      biochemical markers were significantly increased in OWB, indicating that many 
      low-grade inflammatory processes are already involved in the development of 
      obesity in childhood.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Utsal, L
AU  - Utsal L
AD  - University of Tartu, Tartu, Estonia. liina.utsal@ut.ee
FAU - Tillmann, V
AU  - Tillmann V
FAU - Zilmer, M
AU  - Zilmer M
FAU - Maestu, J
AU  - Maestu J
FAU - Purge, P
AU  - Purge P
FAU - Jurimae, J
AU  - Jurimae J
FAU - Saar, M
AU  - Saar M
FAU - Latt, E
AU  - Latt E
FAU - Maasalu, K
AU  - Maasalu K
FAU - Jurimae, T
AU  - Jurimae T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120724
PL  - Switzerland
TA  - Horm Res Paediatr
JT  - Hormone research in paediatrics
JID - 101525157
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Body Mass Index
MH  - C-Reactive Protein/*analysis
MH  - Case-Control Studies
MH  - Chemokine CCL2/*blood
MH  - Child
MH  - Humans
MH  - Ideal Body Weight/physiology
MH  - Interferon-gamma/*blood
MH  - Interleukin-6/*blood
MH  - Interleukin-8/*blood
MH  - Male
MH  - Obesity/*blood/epidemiology
MH  - Overweight/blood/epidemiology
MH  - Skinfold Thickness
EDAT- 2012/07/27 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/07/27 06:00
PHST- 2011/12/07 00:00 [received]
PHST- 2012/05/31 00:00 [accepted]
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - 000339831 [pii]
AID - 10.1159/000339831 [doi]
PST - ppublish
SO  - Horm Res Paediatr. 2012;78(1):31-9. doi: 10.1159/000339831. Epub 2012 Jul 24.