PMID- 22832282
OWN - NLM
STAT- MEDLINE
DCOM- 20130919
LR  - 20211021
IS  - 1879-0046 (Electronic)
IS  - 0376-8716 (Print)
IS  - 0376-8716 (Linking)
VI  - 127
IP  - 1-3
DP  - 2013 Jan 1
TI  - Changes in ambient temperature differentially alter the thermoregulatory, cardiac 
      and locomotor stimulant effects of 4-methylmethcathinone (mephedrone).
PG  - 248-53
LID - S0376-8716(12)00277-3 [pii]
LID - 10.1016/j.drugalcdep.2012.07.003 [doi]
AB  - BACKGROUND: The substituted cathinone compound known as mephedrone 
      (4-methylmethcathinone; 4-MMC) has become popular with recreational users of 
      psychomotor-stimulant compounds. Only recently have the first preclinical studies 
      provided information about this drug in the scientific literature; nevertheless, 
      media reports have led to drug control actions in the UK and across several US 
      states. Rodent studies indicate that 4-MMC exhibits neuropharmacological 
      similarity to 3,4-methylenedioxymethamphetamine (MDMA) and prompt investigation 
      of the thermoregulatory, cardiac and locomotor effects of 4-MMC. This study 
      focuses on the role of ambient temperature, which has been shown to shift the 
      effects of MDMA from hyperthermic to hypothermic. METHODS: Male Sprague-Dawley 
      rats were monitored after subcutaneous administration of 4-MMC (1.0-5.6 mg/kg) 
      using an implantable radiotelemetry system under conditions of low (20  degrees C) and 
      high (30  degrees C) ambient temperature. RESULTS: A pharmacokinetic study found a T(max) 
      of 0.25 h and a C(max) of 1206 ng/ml after 5.6 mg/kg 4-MMC. A dose-dependent 
      reduction of body temperature was produced by 4-MMC at 20  degrees C but there was no 
      temperature change at 30  degrees C. Increased locomotor activity was observed after 
      4-MMC administration under both ambient temperatures, however, significantly more 
      activity was observed at 30  degrees C. Heart rate was slowed by 1.0 and 5.6 mg/kg 4-MMC 
      at 20 degrees C, and was slower in the 30  degrees C vs. 20  degrees C condition across all treatments. 
      CONCLUSION: These results show that the cathinone analog 4-MMC exhibits in vivo 
      thermoregulatory properties that are distinct from those produced by MDMA.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Miller, M L
AU  - Miller ML
AD  - Committee on the Neurobiology of Addictive Disorders, The Scripps Research 
      Institute, La Jolla, CA 92037, USA.
FAU - Creehan, K M
AU  - Creehan KM
FAU - Angrish, D
AU  - Angrish D
FAU - Barlow, D J
AU  - Barlow DJ
FAU - Houseknecht, K L
AU  - Houseknecht KL
FAU - Dickerson, T J
AU  - Dickerson TJ
FAU - Taffe, M A
AU  - Taffe MA
LA  - eng
GR  - DA024705/DA/NIDA NIH HHS/United States
GR  - R01 DA024705/DA/NIDA NIH HHS/United States
GR  - R01 DA024105/DA/NIDA NIH HHS/United States
GR  - R01 DA018418/DA/NIDA NIH HHS/United States
GR  - DA024105/DA/NIDA NIH HHS/United States
GR  - DA018418/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120723
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
RN  - 0 (Illicit Drugs)
RN  - 44RAL3456C (Methamphetamine)
RN  - 8BA8T27317 (mephedrone)
SB  - IM
MH  - Animals
MH  - Body Temperature/*drug effects/physiology
MH  - Body Temperature Regulation/*drug effects/physiology
MH  - Dose-Response Relationship, Drug
MH  - Heart Rate/*drug effects/physiology
MH  - Illicit Drugs/*pharmacology
MH  - Male
MH  - Methamphetamine/*analogs & derivatives/pharmacology
MH  - Motor Activity/*drug effects/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Temperature
PMC - PMC3491086
MID - NIHMS394925
COIS- Conflict of Interest The authors do not have any financial or other conflicts of 
      interest to declare in relationship to this work.
EDAT- 2012/07/27 06:00
MHDA- 2013/09/21 06:00
PMCR- 2014/01/01
CRDT- 2012/07/27 06:00
PHST- 2012/05/30 00:00 [received]
PHST- 2012/07/05 00:00 [revised]
PHST- 2012/07/09 00:00 [accepted]
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - S0376-8716(12)00277-3 [pii]
AID - 10.1016/j.drugalcdep.2012.07.003 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 2013 Jan 1;127(1-3):248-53. doi: 
      10.1016/j.drugalcdep.2012.07.003. Epub 2012 Jul 23.