PMID- 22833197
OWN - NLM
STAT- MEDLINE
DCOM- 20130404
LR  - 20211021
IS  - 2158-3188 (Electronic)
IS  - 2158-3188 (Linking)
VI  - 1
IP  - 10
DP  - 2011 Oct 25
TI  - BDNF polymorphism predicts the rate of decline in skilled task performance and 
      hippocampal volume in healthy individuals.
PG  - e51
LID - 10.1038/tp.2011.47 [doi]
AB  - Numerous studies have indicated a link between the presence of polymorphism in 
      brain-derived neurotrophic factor (BDNF) and cognitive and affective disorders. 
      However, only a few have studied these effects longitudinally along with 
      structural changes in the brain. This study was carried out to investigate 
      whether valine-to-methionine substitution at position 66 (val66met) of pro-BDNF 
      could be linked to alterations in the rate of decline in skilled task performance 
      and structural changes in hippocampal volume. Participants consisted of 144 
      healthy Caucasian pilots (aged 40-69 years) who completed a minimum of 3 
      consecutive annual visits. Standardized flight simulator score (SFSS) was 
      measured as a reliable and quantifiable indicator for skilled task performance. 
      In addition, a subset of these individuals was assessed for hippocampal volume 
      alterations using magnetic resonance imaging. We found that val66met substitution 
      in BDNF correlated longitudinally with the rate of decline in SFSS. Structurally, 
      age-dependent hippocampal volume changes were also significantly altered by this 
      substitution. Our study suggests that val66met polymorphism in BDNF can be linked 
      to the rate of decline in skilled task performance. Furthermore, this 
      polymorphism could be used as a predictor of the effects of age on the structure 
      of the hippocampus in healthy individuals. Such results have implications for 
      understanding possible disabilities in older adults performing skilled tasks who 
      are at a higher risk for cognitive and affective disorders.Translational 
      Psychiatry (2011) 1, e51; doi:10.1038/tp.2011.47; published online 25 October 
      2011.
FAU - Sanchez, M Millan
AU  - Sanchez MM
AD  - VA Palo Alto Health Care System, Palo Alto, CA 94304, USA.
FAU - Das, D
AU  - Das D
FAU - Taylor, J L
AU  - Taylor JL
FAU - Noda, A
AU  - Noda A
FAU - Yesavage, J A
AU  - Yesavage JA
FAU - Salehi, A
AU  - Salehi A
LA  - eng
GR  - P30 AG017824/AG/NIA NIH HHS/United States
GR  - R01 AG021632/AG/NIA NIH HHS/United States
GR  - P41 RR023953/RR/NCRR NIH HHS/United States
GR  - R01AG021632/AG/NIA NIH HHS/United States
GR  - P30 AG17824/AG/NIA NIH HHS/United States
GR  - R37 AG012713/AG/NIA NIH HHS/United States
GR  - R37 AG12713/AG/NIA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20111025
PL  - United States
TA  - Transl Psychiatry
JT  - Translational psychiatry
JID - 101562664
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - *Aerospace Medicine
MH  - Aged
MH  - Amino Acid Substitution/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cross-Sectional Studies
MH  - Female
MH  - Hippocampus/*anatomy & histology/physiology/*physiopathology
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Motor Skills/*physiology
MH  - Polymorphism, Genetic/*genetics
MH  - Predictive Value of Tests
MH  - Psychomotor Performance/classification/*physiology
MH  - United States
MH  - Workforce
PMC - PMC3309489
EDAT- 2011/01/01 00:00
MHDA- 2013/04/05 06:00
PMCR- 2011/10/01
CRDT- 2012/07/27 06:00
PHST- 2012/07/27 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2013/04/05 06:00 [medline]
PHST- 2011/10/01 00:00 [pmc-release]
AID - tp201147 [pii]
AID - 10.1038/tp.2011.47 [doi]
PST - epublish
SO  - Transl Psychiatry. 2011 Oct 25;1(10):e51. doi: 10.1038/tp.2011.47.