PMID- 22833214
OWN - NLM
STAT- MEDLINE
DCOM- 20130329
LR  - 20131121
IS  - 1520-6017 (Electronic)
IS  - 0022-3549 (Linking)
VI  - 101
IP  - 10
DP  - 2012 Oct
TI  - Evaluation of water uptake and mechanical properties of blended polymer films for 
      preparing gas-generated multiple-unit floating drug delivery systems.
PG  - 3811-22
LID - 10.1002/jps.23279 [doi]
AB  - Among various strategies of gastroretentive drug delivery systems (DDSs) 
      developed to prolong the gastric residence time and to increase the overall 
      bioavailability, effervescent multiple-unit floating DDSs (muFDDSs) were studied 
      here. These systems consist of drug (losartan)- and effervescent (sodium 
      bicarbonate)-containing pellets coated with a blended polymeric membrane, which 
      was a mixture of gastrointestinal tract (GIT)-soluble and GIT-insoluble polymers. 
      The addition of GIT-soluble polymers, such as hydroxypropyl methylcellulose, 
      polyethylene glycol (PEG) 6000, PEG 600, and Kollicoat(R) IR, greatly increased the 
      water uptake ability of the GIT-insoluble polymers (Eudragit(R) NE, RS, and RL; 
      Surelease(R); and Kollicoat(R) SR) and caused them to immediately initiate the 
      effervescent reaction and float, but the hydrated films should also be 
      impermeable to the generated CO(2) to maintain floatation and sufficiently 
      flexible to withstand the pressure of carbon dioxide to avoid rupturing. The 
      study demonstrated that the water uptake ability and mechanical properties could 
      be applied as screening tools during the development of effervescent muFDDSs. The 
      optimized system of SRT(5)P600(5) (i.e., a mixture of 5% Kollicoat(R) SR and 5% PEG 
      600) with a 20% coating level began to completely float within 15 min and 
      maintained its buoyancy over a period of 12 h with a sustained-release effect.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Chen, Ying-Chen
AU  - Chen YC
AD  - School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, 
      Taiwan.
FAU - Lee, Lin-Wen
AU  - Lee LW
FAU - Ho, Hsiu-O
AU  - Ho HO
FAU - Sha, Chen
AU  - Sha C
FAU - Sheu, Ming-Thau
AU  - Sheu MT
LA  - eng
PT  - Journal Article
DEP - 20120725
PL  - United States
TA  - J Pharm Sci
JT  - Journal of pharmaceutical sciences
JID - 2985195R
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Gases)
RN  - 0 (Polymers)
RN  - 059QF0KO0R (Water)
RN  - 142M471B3J (Carbon Dioxide)
RN  - 8MDF5V39QO (Sodium Bicarbonate)
RN  - JMS50MPO89 (Losartan)
SB  - IM
MH  - Biological Availability
MH  - Carbon Dioxide/chemistry
MH  - Delayed-Action Preparations/*chemistry
MH  - Drug Delivery Systems/methods
MH  - Gases/*chemistry
MH  - Gastrointestinal Tract/metabolism
MH  - Losartan/chemistry
MH  - Polymers/*chemistry
MH  - Sodium Bicarbonate/chemistry
MH  - Water/*chemistry
EDAT- 2012/07/27 06:00
MHDA- 2013/03/30 06:00
CRDT- 2012/07/27 06:00
PHST- 2011/12/19 00:00 [received]
PHST- 2012/06/25 00:00 [revised]
PHST- 2012/07/06 00:00 [accepted]
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2013/03/30 06:00 [medline]
AID - S0022-3549(15)31409-X [pii]
AID - 10.1002/jps.23279 [doi]
PST - ppublish
SO  - J Pharm Sci. 2012 Oct;101(10):3811-22. doi: 10.1002/jps.23279. Epub 2012 Jul 25.