PMID- 22835336
OWN - NLM
STAT- MEDLINE
DCOM- 20130131
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 80
IP  - 4
DP  - 2012 Oct
TI  - Major histocompatibility complex class I chain related gene-A microsatellite 
      polymorphism shows secondary association with type 1 diabetes and celiac disease 
      in North Indians.
PG  - 356-62
LID - 10.1111/j.1399-0039.2012.01931.x [doi]
AB  - Microsatellite polymorphism in exon 5 of major histocompatibility complex class I 
      chain related gene-A (MIC-A) has been implicated in the etiology of autoimmune 
      diseases including type 1 diabetes (T1D) and celiac disease (CD). In this study 
      on North Indian population, the MIC-A5.1 allele, carrying a premature termination 
      codon in transmembrane region, was observed with increased frequency in T1D 
      (29.6%, odds ratio OR = 2.1, P = 0.00017) and CD patients (40.3%, OR = 3.37, 
      P = 1.67E-05) than in controls (16.7%). When the MIC-A5.1 association was 
      adjusted for linkage with human leukocyte antigen (HLA)-DR3, the statistical 
      significance of the association was abolished. This implies that the observed 
      association of MIC-A5.1 is due to its linkage disequilibrium (D' = 0.94) with 
      HLA-B8-DR3-DQ2 haplotype and is secondary to the overall association with DR3 
      positive MHC haplotypes.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - Kumar, N
AU  - Kumar N
AD  - Department of Transplant Immunology and Immunogenetics, All India Institute of 
      Medical Sciences, New Delhi, India.
FAU - Sharma, G
AU  - Sharma G
FAU - Kaur, G
AU  - Kaur G
FAU - Tandon, N
AU  - Tandon N
FAU - Bhatnagar, S
AU  - Bhatnagar S
FAU - Mehra, N
AU  - Mehra N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120726
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-B8 Antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (HLA-DR3 Antigen)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
RN  - 0 (Protein Isoforms)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Celiac Disease/*genetics/immunology
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/*genetics/immunology
MH  - Female
MH  - Gene Frequency
MH  - HLA-B8 Antigen/genetics/immunology
MH  - HLA-DQ Antigens/genetics/immunology
MH  - HLA-DR3 Antigen/genetics/immunology
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics/immunology
MH  - Humans
MH  - India
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Protein Isoforms/genetics/immunology
MH  - White People
EDAT- 2012/07/28 06:00
MHDA- 2013/02/01 06:00
CRDT- 2012/07/28 06:00
PHST- 2012/03/22 00:00 [received]
PHST- 2012/05/29 00:00 [revised]
PHST- 2012/06/26 00:00 [accepted]
PHST- 2012/07/28 06:00 [entrez]
PHST- 2012/07/28 06:00 [pubmed]
PHST- 2013/02/01 06:00 [medline]
AID - 10.1111/j.1399-0039.2012.01931.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2012 Oct;80(4):356-62. doi: 10.1111/j.1399-0039.2012.01931.x. 
      Epub 2012 Jul 26.